ArticleHealth science reports2026
The Association Between PIV and Mortality in US Stroke Survivors: A NHANES 1999-2018 Retrospective Cohort Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The Association Between PIV and Mortality in US Stroke Survivors: A NHANES 1999-2018 Retrospective Cohort Study.Health science reports · 2026Article
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Stroke is a leading cause of mortality and disability worldwide. The pan-immune-inflammation value (PIV) has emerged as a composite marker of systemic immune-inflammatory status. We aimed to investigate the association of PIV with mortality in US adults with a history of stroke. Methods: We analyzed 1948 participants in the 1999-2018 National Health and Nutrition Examination Survey (NHANES). Baseline PIV was calculated from routine blood counts as (neutrophils × platelets × monocytes ÷ lymphocytes). Mortality outcomes were ascertained through linked death records. A generalized additive model incorporating restricted cubic splines was employed to characterize the dose-response relationship between PIV and mortality risk. When statistically significant nonlinearity was detected in the exposure-outcome association, a two-piecewise Cox proportional hazards model was applied to estimate hazard ratios for each segment. Results: Among 1948 participants, 904 deaths (46.4%) occurred over a median follow-up of 75 months; the mean age was 66.8 ± 13.3 years. PIV exhibited a statistically significant J-shaped association with all-cause mortality ( Conclusion: Among US stroke survivors, both abnormally low and high PIV levels were associated with an increased risk of mortality in a J-shaped pattern. As a composite index derived from routine blood counts, PIV may serve as an accessible candidate indicator for risk assessment in stroke survivors, though prospective studies are needed to validate these findings and elucidate the underlying mechanisms.
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