ArticleBiomedical optics express2026
Quantitative dynamic full-field optical coherence tomography for high-resolution intraoperative imaging of head and neck squamous cell carcinoma.
Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
We present a dynamic full-field optical coherence tomography (D-FFOCT) system providing both structural and dynamic contrast for label-free imaging of head and neck squamous cell carcinoma (HNSCC). The system simultaneously acquires structural and dynamic contrast, enabling visualization of tissue morphology and intracellular activity. Ex vivo imaging of MTCQ1 xenografts and fresh human HNSCC specimens showed distinct patterns between tumor and normal tissues, consistent with H&E histology. Dynamic contrast remained stable for 4 h after excision. Quantitative ROI analysis revealed significant differences in epithelial morphology and temporal fluctuation metrics, supporting rapid intraoperative optical characterization of HNSCC.
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