ArticleBiomedical optics express2026
Spectroscopic correlation tomography (SpCT) for visualization of spatial correlations in volumetric OCT scans.
Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Spectroscopic optical coherence tomography (SOCT) allows for the targeted analysis of cell nuclei due to their spectrally distinct scattering properties. SOCT has been explored for optical biopsy based on its ability to extract structural and spectroscopic properties of a sample without the need for labels. Using the dual-window method for SOCT, spatial correlations can be computed throughout volumetric scans and analyzed to determine the size of cell nuclei. Such analysis could enable quantitative visualization of tissue boundaries that appear homogenous in structural OCT images. Here, we present spectroscopic correlation tomography (SpCT), a technique for mapping spatial correlation measurements to a hue-saturation-value (HSV) color space to help visualize relative changes in spatial correlation throughout volumetric OCT samples. SpCT B-Scans and volumes of polystyrene bead samples with diameters 5.1 μm to 11.3 μm were acquired and scatterer sizes were quantified using a Gaussian mixture model, achieving size estimates within half-wavelength accuracy. 3T3 fibroblasts were imaged and analyzed via connected component analysis, producing strong agreement with scatterer size measured via confocal microscopy, thus validating our approach. Histology versus SpCT B-Scan comparisons were performed for human colon organoids, cardiac organoids, and human lung airway explant to demonstrate this technique's ability to identify varying degrees of nuclear morphology in different regions. SpCT volumes were used to objectively discriminate between control and
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