ArticleJournal of tissue engineering
Synergistic Wnt/BMP Co-activation accelerates osteogenic differentiation of human pluripotent stem cells via paraxial mesoderm induction.
Article in Journal of tissue engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
9 authors.
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Abstract
Bone healing is a complex and well-organized process, regulated by various factors ranging from growth factors to hormones, cytokines, mechanical stimuli, and aging. Recently, numerous techniques have been devised to efficiently induce the differentiation of human induced pluripotent stem cells (hiPSCs) to osteoblasts. However, enhancing the efficiency of osteoblast differentiation remains a challenge. Thus, we induced the differentiation of hiPSCs to mesodermal cells through Wnt/BMP signaling based on the generation of hiPSCs. After successful generation of hiPSCs, we induced the differentiation of mesodermal cells to osteoblasts. The results revealed that the runt-related transcription factor 2 (
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Registered trials
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