ReviewMolecular therapy. Advances2026
Designs of the clinical trials aiming at evaluating cell and gene therapy products: A critical appraisal from a literature review.
Review in Molecular therapy. Advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
There is growing interest in advanced therapy medicinal products (ATMPs). However, there is debate about how they should be clinically evaluated. We aimed to assess the heterogeneity of trial designs used for ATMPs, based on a review of the most recently published ATMP trials from 2022 to 2024, and then make recommendations to improve the level of evidence. The 276 selected trials concerned CAR-T cells (28%), other gene therapies (22%), and somatic cell therapy (50%) and targeted different underlying diseases, hematological malignancies for CAR-T cells, genetic or congenital diseases for gene therapy, and other diseases for somatic cells (
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.