Evidence map›Paper›PMID 42460631›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Inhibition of IGFBP4 in Granulosa Cells Improves Reproductive Performance and Maintains Fertility With Age via YAP Signaling.

Qianhui Hu, Ajun Geng, Ziyuan Li, Fanghao Guo, Jingqiang Wang, Xinyi Chen, Meiling Zhang, Yi Arial Zeng, Wen Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qianhui HuCenter For Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0009-0005-6837-0635
Ajun GengState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Ziyuan LiThe Center of Reproductive Medicine, Shanghai Changzheng Hospital, Naval Medical University, Shanghai, China.
Fanghao GuoCenter For Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China.
Jingqiang WangState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Xinyi ChenKey Laboratory of Systems Health Science of Zhejiang Province, School of Life Science, Hangzhou Institute for Advanced Study, Hangzhou, University of Chinese Academy of Sciences, China.
Meiling ZhangCenter For Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China.
Yi Arial ZengState Key Laboratory of Cell Biology, CAS Center for Excellence in Molecular Cell Science, Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China.
Wen LiCenter For Reproductive Medicine & Fertility Preservation Program, School of Medicine, International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University, Shanghai, China.ORCID https://orcid.org/0000-0001-9468-5570

Funding

National Natural Science Foundation of China 32300690National Natural Science Foundation of China 32588301National Natural Science Foundation of China 82371726New Cornerstone Science Foundation NCI202254Science and Technology Commission of Shanghai Municipality 23J21901400Shanghai Municipal Science and Technology Major Project, CAS-Croucher Funding Scheme for Joint Laboratories CAS24801：CAS24SC02the CAS Project for Young Scientists in Basic Research YSBR-014the Joint Funds of the National Natural Science Foundation of China U24A20658
6 · The paper itself

Abstract

Ovarian aging is a critical factor influencing reproductive capacity and overall health. Granulosa cells (GCs) play essential roles in folliculogenesis; however, the mechanisms by which GC dysfunction contributes to ovarian aging remain incompletely understood. In this study, we identified insulin-like growth factor binding protein 4 (IGFBP4) as a negative regulator of ovarian function that is upregulated in GCs from aged cynomolgus monkey ovaries. Using an Igfbp4-HA tagged mouse model, we found that IGFBP4 expression in GCs increased during follicle development and was further elevated in aged mice. RNA-seq analysis of Igfbp4-deficient GCs revealed activation of the YAP pathway, which supports follicular development. Mechanistically, IGFBP4 reduced YAP nuclear localization in GCs, thereby restraining downstream YAP target gene expression and GC proliferation. In Amhr2-Cre; Igfbp4

Indexed as

female fertilitygranulosa cellsIGFBP4ovarian agingyes‐associated protein signaling

Identifiers

PMID42460631
PMCPMC13373898

What Socratic holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.