Evidence map›Paper›PMID 42460749›Full record

ArticleChemistry & biodiversity2026

In Vitro and In Silico Investigations of Antifungal Activity of Ethyl Acetate Extracts of Various Species of Swertia Against Aspergillus fumigatus.

Divyansh Panthari, Kanchan Bhardwaj, Vinita Gouri, Subhash Chandra, Sarkar M A Kawsar

Abstract read
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In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Divyansh PanthariDepartment of Botany, School of Basic & Applied Sciences, Shri Guru Ram Rai University, Dehradun, Uttarakhand, India.ORCID https://orcid.org/0009-0007-1357-3819
Kanchan BhardwajDepartment of Botany, School of Basic & Applied Sciences, Shri Guru Ram Rai University, Dehradun, Uttarakhand, India.ORCID https://orcid.org/0000-0002-1708-6395
Vinita GouriCell and Molecular Biology Laboratory, Department of Zoology, Soban Singh Jeena University Campus, Almora, Uttarakhand, India.ORCID https://orcid.org/0009-0009-8851-5300
Subhash ChandraDepartment of Chemistry, School of Basic & Applied Sciences, Shri Guru Ram Rai University, Dehradun, Uttarakhand, India.ORCID https://orcid.org/0000-0001-8440-7825
Sarkar M A KawsarLaboratory of Carbohydrate and Nucleoside Chemistry (LCNC), Department of Chemistry, Faculty of Science, University of Chittagong, Chittagong, Bangladesh.ORCID https://orcid.org/0000-0001-7964-9117

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The increased resistance of A. fumigatus to antifungal agents highlights the need for the development of novel therapeutics from natural sources. The present study aimed to assess the antifungal activity of four Swertia species (S. chirayita, S. purpurascens, S. paniculata and S. cordata) using both in vitro and in silico methods. Agar well diffusion and minimum inhibitory concentration (MIC) tests were used to measure in vitro antifungal activity. Gas chromatography‒mass spectrometry (GC‒MS) analysis was performed to identify phytochemicals, which were subsequently docked against glucosamine-6-phosphate N-acetyltransferase (Gna1), an essential enzyme in fungal cell wall biosynthesis. The pharmacokinetics and toxicity of the top candidates were further assessed via absorption, distribution, metabolism, excretion, and toxicity (ADMET) analyses. The extract of S. paniculata presented the greatest antifungal activity, followed by that of S. chirayita, whose inhibition diameters were 16.50 ± 0.4

Indexed as

AcetatesAntifungal AgentsAspergillus fumigatusPlant ExtractsSwertiaGas Chromatography-Mass SpectrometryMicrobial Sensitivity TestsMolecular Docking SimulationStructure-Activity RelationshipAcetatesAntifungal Agentsethyl acetatePlant ExtractsADMETAspergillus fumigatusglucosamine‐6‐phosphate N‐acetyl transferasemolecular dockingSwertia

Identifiers

PMID42460749
PMCPMC13373979

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.