Evidence map›Paper›PMID 42460976›Full record

ArticleSleep2026

Automated deep learning-based arousal detection agrees with ten expert scorers in unseen data.

Henna Pitkänen, Riku Huttunen, Masoumeh Tashakori, Marika Rissanen, Matias Rusanen, Heidur Gretarsdottir, Erna Sif Arnardottir, Tiina Paunio, Antti Kulkas, Sami Nikkonen and 2 more

Abstract read
In one paragraph

Article in Sleep, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Henna PitkänenDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0001-5100-3816
Riku HuttunenDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0001-8290-4764
Masoumeh TashakoriDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0001-5117-3065
Marika RissanenDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0003-0842-8872
Matias RusanenDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0001-9633-6016
Heidur GretarsdottirReykjavik University Sleep Institute, School of Technology, Reykjavik University, Reykjavik, Iceland.
Erna Sif ArnardottirReykjavik University Sleep Institute, School of Technology, Reykjavik University, Reykjavik, Iceland.ORCID 0000-0003-0877-3529
Tiina PaunioDepartment of Psychiatry and SleepWell Research Program, Faculty of Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.ORCID 0000-0002-5560-0666
Antti KulkasDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0001-8252-3996
Sami NikkonenDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0003-0615-4118
Timo LeppänenDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0003-4017-821X
Henri KorkalainenDepartment of Technical Physics, University of Eastern Finland, Kuopio, Finland.ORCID 0000-0002-4686-6112

Funding

Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
ASSOCIATION OF SLEEP DISORDERS WITH CARDIOVASCULAR HEALTH ACROSS ETHNIC GROUPSR01HL098433 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2010 to 2015
$8.2M
National Sleep Research Resource (NSRR)R24HL114473 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S., ZHANG, GUO-QIANG · 2013 to 2017
$7.5M
SUBCLINICAL CARDIOVASCULAR DISEASE STUDYN01HC095166 · HC · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI TRACY, RUSSELL P · 1999 to 2001
$758k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095162 · HC · JOHNS HOPKINS UNIVERSITY · PI SZKLO, MOYSES A · 1999 to 2000
$694k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095161 · HC · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHEA, STEVEN · 1999 to 2001
$642k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095165 · HC · WAKE FOREST UNIVERSITY · PI BURKE, GREGORY L · 1999 to 2001
$616k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095160 · HC · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAAD, MOHAMMED F · 1999 to 2001
$592k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-FIELD CENTERN01HC095164 · HC · NORTHWESTERN UNIVERSITY · PI LIU, KIANG JOHN · 1999 to 2001
$511k
SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--FIELD CENTERN01HC095163 · HC · UNIVERSITY OF MINNESOTA TWIN CITIES · PI FOLSOM, AARON R · 1999 to 2001
$443k
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS R01 HL098433NHLBI NIH HHS R24 HL114473
6 · The paper itself

Abstract

STUDY

objectivesAutomatic arousal scoring is essential for the cost-effective analysis of polysomnograms. Many previous automatic methods have been tested in homogeneous, single-center datasets, and all against one scorer, on event-by-event basis, or in 30-s segments. We developed a deep learning-based arousal scoring model and tested it at 1-s resolution in an independent dataset scored by ten expert scorers from seven different sleep centers. MATERIALS AND

methodsA fully convolutional neural network model was developed using 1847 openly available polysomnograms from the Multi-Ethnic Study of Atherosclerosis (MESA) and tested in 205 hold-out polysomnograms from the MESA cohort, and in an independent Sleep Revolution (SR) cohort of 50 polysomnograms, each scored by ten scorers. Model performance was evaluated on an event-by-event basis and in 1-s segments. In the SR dataset, the performance was tested against each scorer individually and against their majority agreement.

resultsIn the MESA test set, the model achieved an event-by-event F1-score of 0.77, a 1-s segment κ-value of 0.67, and an arousal index (ArI) intraclass correlation coefficient (ICC) of 0.83. In the multi-scorer SR dataset, the model reached a median event-by-event F1-score, a 1-s κ-value, and an ArI ICC of 0.61, 0.50, and 0.66, respectively, exceeding the corresponding median values of the scorers among themselves (0.57, 0.46, and 0.59, respectively).

conclusionsThe model achieved higher median arousal scoring agreement with ten manual scorers than the scorers did among themselves in an independent dataset. This suggests that the model generalizes well and can reliably be used in different sleep recordings.

Indexed as

ArousalDeep LearningPolysomnographyConvolutional Neural NetworksFemaleHumansMalearousalautomatic scoringdeep learningelectroencephalograminterobserver agreementneural networksleep fragmentation

Identifiers

PMID42460976
PMCPMC13658263

What Socratic holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.