ArticleTropical animal health and production2026
Genomic investigation of the fat-to-protein ratio: functional analysis of a biomarker associated with ketosis in Iranian Holstein dairy cows.
Article in Tropical animal health and production, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The milk fat-to-protein ratio (FPR) is an important indicator of milk quality and a useful biomarker of metabolic status in dairy cows. This study used functional single-step genome-wide association analysis (ssGWAS) incorporating performance records from 502,781 first-parity Iranian Holstein cows and SNP genotypes from 2,187 Holstein bulls to investigate the genomic architecture underlying FPR variation in this population. The heritability of FPR was estimated at 0.24. Genome-wide scanning identified 18 significant SNPs on BTA14 and 121 positional candidate genes located within ± 100 kb of these variants. Because FPR is commonly used as a biomarker for metabolic disorders such as ketosis, we additionally performed Gene Ontology (GO) enrichment analysis to identify biological pathways and genes potentially involved in subclinical ketosis risk. The major enriched pathways were related to lipid metabolism, energy utilization, and acylglycerol biosynthesis. Several significant SNPs-particularly ARS-BFGL-NGS-4939, ARS-BFGL-NGS-94,706, ARS-BFGL-NGS-103,064, ARS-BFGL-NGS-3122, and Hapmap29758-BTC-003619-were located near key functional genes such as DGAT1, CYP11B1, and GPIHBP1, which have known roles in these pathways and may contribute to FPR variability and susceptibility to subclinical ketosis. Overall, our findings provide new insight into the genomic basis of FPR and offer valuable direction for breeding strategies aimed at reducing ketosis prevalence in Iranian Holstein cattle.
Indexed as
Identifiers
42461360What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.