Evidence map›Paper›PMID 42461366›Full record

ArticleClinical transplantation2026

Expanding the Pancreas Donor Pool: Reassessing the Impact of Donor Body Mass Index on Transplant Outcomes.

Alexander Jurkovich, Tiffany Lim, Emma S Crichton, Tia Ketsan, Evronia Baselious, Yujie Cui, Georgios Voidonikolas, Kambiz Kosari, Nicholas N Nissen, Tsuyoshi Todo and 4 more

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Article in Clinical transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alexander JurkovichUniversity of Southern California, Los Angeles, California, USA.
Tiffany LimDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Emma S CrichtonDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Tia KetsanUniversity of California Los Angeles, Los Angeles, California, USA.
Evronia BaseliousUniversity of California Los Angeles, Los Angeles, California, USA.
Yujie CuiDepartment of Biostatistics and Bioinformatics, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Georgios VoidonikolasDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Kambiz KosariDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Nicholas N NissenDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Tsuyoshi TodoDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Justin A SteggerdaDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Steven A WiselDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Irene K KimDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Todd V BrennanDepartment of Surgery, Cedars-Sinai Medical Center, Los Angeles, California, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreas transplantation in the United States has declined over the past 20 years, in part because restrictive donor selection practices, particularly around obesity, contribute to high organ turndown rates. This retrospective study used data from the Organ Procurement and Transplantation Network (OPTN) to assess whether donor body mass index (BMI) affects outcomes after primary simultaneous pancreas-kidney transplantation. The analysis included 9519 adult recipients transplanted from 2010 through 2022. Donors were categorized by BMI as underweight, normal weight, overweight, or obese. Kaplan-Meier analysis, Cox proportional hazards models, and restricted cubic spline modeling were used to compare outcomes across groups. Donor BMI was not associated with significant differences in one- or three-year patient survival or death-censored pancreas and kidney graft survival, and multivariable Cox regression analysis found donor BMI to not be an independent predictor of graft loss. Instead, factors associated with one-year graft failure included donor age over 45 years, cerebrovascular accident as the cause of death, and cold ischemia time longer than 12 h. These findings indicate that carefully selected pancreata from donors with higher BMI can achieve outcomes comparable to those from normal-weight donors, supporting reconsideration of BMI-based exclusion criteria to expand the donor pool and increase pancreas transplantation rates.

Indexed as

Body Mass IndexDonor SelectionGraft RejectionKidney TransplantationPancreas TransplantationPostoperative ComplicationsTissue and Organ ProcurementTissue DonorsAdultFemaleFollow-Up StudiesGraft SurvivalHumansMaleMiddle AgedPrognosisbody mass indexgraft survivalobesityorgan donationpancreas transplantationpatient survivaltransplant outcomes

Identifiers

PMID42461366
PMCPMC13374671

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.