Evidence map›Paper›PMID 42462158›Full record

Observational studyESC heart failure2026

Severe tricuspid regurgitation: aetiology, patient characteristics, and treatment: a multicentre, prospective registry.

Agnieszka Kapłon-Cieślicka, Adam Piasecki, Karolina Semczuk-Kaczmarek, Katarzyna Holcman, Sylwia Szczepara, Grzegorz Kopeć, Agata Krawczyk-Ożóg, Renata Rajtar-Salwa, Danuta Sorysz, Karol Kamiński and 45 more

Abstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in ESC heart failure, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

55 authors.

Agnieszka Kapłon-Cieślicka1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1A, Warsaw 02-097, Poland.
Adam Piasecki1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1A, Warsaw 02-097, Poland.ORCID 0009-0002-5614-6415
Karolina Semczuk-Kaczmarek1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1A, Warsaw 02-097, Poland.
Katarzyna HolcmanDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, Institute of Cardiology, St. John Paul II Hospital, Kraków, Poland.ORCID 0000-0002-6895-4076
Sylwia SzczeparaDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, Institute of Cardiology, St. John Paul II Hospital, Kraków, Poland.
Grzegorz KopećDepartment of Cardiac and Vascular Diseases, Jagiellonian University Medical College, Institute of Cardiology, St. John Paul II Hospital, Kraków, Poland.
Agata Krawczyk-OżógDepartment of Cardiology and Cardiovascular Interventions, University Hospital, Kraków, Poland.
Renata Rajtar-SalwaDepartment of Cardiology and Cardiovascular Interventions, University Hospital, Kraków, Poland.
Danuta SoryszDepartment of Cardiology and Cardiovascular Interventions, University Hospital, Kraków, Poland.
Karol KamińskiDepartment of Cardiology and Internal Medicine with Cardiac Intensive Care Unit, Medical University of Bialystok, Bialystok, Poland.
Małgorzata KnappDepartment of Cardiology and Internal Medicine with Cardiac Intensive Care Unit, Medical University of Bialystok, Bialystok, Poland.
Sebastian StelmaszekDepartment of Cardiology and Internal Medicine with Cardiac Intensive Care Unit, Medical University of Bialystok, Bialystok, Poland.
Maria KrólikowskaDepartment of Coronary Disease and Heart Failure, Jagiellonian University, Medical College, St. John Paul II Hospital, Kraków, Poland.
Anna Furman-NiedziejkoDepartment of Coronary Disease and Heart Failure, Jagiellonian University, Medical College, St. John Paul II Hospital, Kraków, Poland.
Andrzej GackowskiDepartment of Coronary Disease and Heart Failure, Jagiellonian University, Medical College, St. John Paul II Hospital, Kraków, Poland.ORCID 0000-0003-4545-6514
Agata Polańska-SzczapDepartment of Cardiology, Kociewie Health Center, Starograd Gdanski, Poland.
Grażyna TuskowskaDepartment of Cardiology, Kociewie Health Center, Starograd Gdanski, Poland.
Marek KozińskiDepartment of Cardiology, Kociewie Health Center, Starograd Gdanski, Poland.
Anna Tomaszuk-KazberukDepartment of Cardiology, Lipidology and Internal Medicine with Intensive Cardiac Care Unit, Medical University of Bialystok, Bialystok, Poland.
Kinga DudzińskaDepartment of Cardiology, Lipidology and Internal Medicine with Intensive Cardiac Care Unit, Medical University of Bialystok, Bialystok, Poland.
Paweł MuszyńskiDepartment of Cardiology, Lipidology and Internal Medicine with Intensive Cardiac Care Unit, Medical University of Bialystok, Bialystok, Poland.
Ludmiła Daniłowicz-SzymanowiczDepartment of Cardiology and Electrotherapy, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Damian KaufmannDepartment of Cardiology and Electrotherapy, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Małgorzata SzwochDepartment of Cardiology and Electrotherapy, Faculty of Medicine, Medical University of Gdansk, Gdansk, Poland.
Beata Uziębło-ŻyczkowskaDepartment of Cardiology and Internal Diseases, Military Institute of Medicine-National Research Institute, Warsaw, Poland.
Małgorzata MaciorowskaDepartment of Cardiology and Internal Diseases, Military Institute of Medicine-National Research Institute, Warsaw, Poland.
Paweł KrzesińskiDepartment of Cardiology and Internal Diseases, Military Institute of Medicine-National Research Institute, Warsaw, Poland.
Agata Markiewicz1st Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
Agnieszka Bartczak-Rutkowska1st Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
Marek Grygier1st Department of Cardiology, Poznan University of Medical Sciences, Poznan, Poland.
Bartosz KijewskiDepartment of Cardiology, Medical University of Lublin, University Centre of Cardiology and Cardiac Surgery, Lublin, Poland.
Robert BłaszczykDepartment of Cardiology, Medical University of Lublin, University Centre of Cardiology and Cardiac Surgery, Lublin, Poland.
Bartosz KondrackiDepartment of Cardiology, Medical University of Lublin, University Centre of Cardiology and Cardiac Surgery, Lublin, Poland.
Piotr Nikodem RudzińskiDepartment of Coronary and Structural Heart Diseases, The Cardinal Stefan Wyszyński National Institute of Cardiology, Warsaw, Poland.
Marcin DemkowDepartment of Coronary and Structural Heart Diseases, The Cardinal Stefan Wyszyński National Institute of Cardiology, Warsaw, Poland.
Mariusz DębskiDepartment of Coronary and Structural Heart Diseases, The Cardinal Stefan Wyszyński National Institute of Cardiology, Warsaw, Poland.
Tomasz Tokarek2nd Clinical Department of Cardiology, Faculty of Medicine and Health Science, University of Applied Science in Nowy Sącz, Nowy Sącz, Poland.
Dominika Dykla2nd Clinical Department of Cardiology, Faculty of Medicine and Health Science, University of Applied Science in Nowy Sącz, Nowy Sącz, Poland.
Aleksander Zeliaś2nd Clinical Department of Cardiology, Faculty of Medicine and Health Science, University of Applied Science in Nowy Sącz, Nowy Sącz, Poland.
Rafał Gałąska1st Department of Cardiology, Medical University of Gdansk, Gdansk, Poland.
Marcin Fijałkowski1st Department of Cardiology, Medical University of Gdansk, Gdansk, Poland.
Małgorzata NiemiecFirst Department of Cardiology, Chair of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.
Katarzyna Mizia-StecFirst Department of Cardiology, Chair of Cardiology, School of Medicine in Katowice, Medical University of Silesia, Katowice, Poland.ORCID 0000-0001-6907-2799
Katarzyna KurnickaIndependent Scientific Echocardiography Laboratory, National Institute of Geriatrics, Rheumatology and Rehabilitation, Warsaw, Poland.
Piotr PruszczykDepartment of Internal Medicine and Cardiology, Medical University of Warsaw, Warsaw, Poland.ORCID 0000-0002-9768-0000
Jerzy PręgowskiDepartment of Interventional Cardiology and Angiology, National Institute of Cardiology, Warsaw, Poland.
Jarosław SkowrońskiDepartment of Interventional Cardiology and Angiology, National Institute of Cardiology, Warsaw, Poland.
Agata Bielecka-DąbrowaDepartment of Preventive Cardiology and Lipidology, Medical University of Lodz, Lodz, Poland.
Karolina KupczyńskaDepartment of Cardiology and Congenital Heart Diseases of Adults, Polish Mother's Memorial Hospital Research Institute (PMMHRI), Lodz, Poland.
Ewa Pędzich1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1A, Warsaw 02-097, Poland.
Ewa Ostrowska1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1A, Warsaw 02-097, Poland.
Mariusz Tomaniak1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1A, Warsaw 02-097, Poland.
Marcin Grabowski1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1A, Warsaw 02-097, Poland.
Piotr Scisło1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1A, Warsaw 02-097, Poland.
Adam Rdzanek1st Chair and Department of Cardiology, Medical University of Warsaw, Banacha 1A, Warsaw 02-097, Poland.ORCID 0000-0002-0235-9696

Funding

PCS Scientific PlatformPolish Cardiac Society
6 · The paper itself

Abstract

BACKGROUND AND

aimsSevere tricuspid regurgitation (TR) is associated with increased mortality and hospitalizations for heart failure (HF). Aetiologies of TR include: secondary (atrial or ventricular), primary and cardiac implantable electronic device (CIED)-related. The aim of the study was to assess the prevalence of different TR aetiologies, as well as characteristics and treatment of patients with severe TR in a real-life setting.

methodsThis was a prospective, observational study of patients with severe TR, conducted in 18 cardiology centres. Consecutive adult patients with severe TR were included, regardless of the presence of TR symptoms and the cause of hospital admission.

resultsA total of 1295 patients with severe TR were enrolled (median age 76 years, 53% women). The most common reason for admission was HF decompensation (40%). Single TR aetiology was identified in 79% patients. The most frequent overlap between aetiologies included secondary ventricular and atrial TR, and was found in 11% of patients. The most common TR aetiology was secondary atrial (37%), followed by secondary ventricular (25%). Primary and CIED-related TR accounted for 10% and 15%, respectively. In 2.4% TR aetiology was not determined. Patients with secondary atrial and CIED-related TR were the oldest (79 and 78 years, respectively), and those with primary TR the youngest (68 years). Patients with CIED-related and secondary ventricular TR were more often hospitalized for HF decompensation, had more advanced HF symptoms, worse left- and right-ventricular function, worse kidney and liver function, and higher in-hospital mortality. Only 40% of patients underwent evaluation by the Heart Team and 21% were qualified for TR interventions.

conclusionsIn real life, unequivocal identification of TR aetiology remains challenging. Secondary atrial TR is the most common aetiology. There are significant differences in characteristics and outcomes depending on TR aetiology. Too few patients with severe TR undergo evaluation by the Heart Team.

Indexed as

RegistriesTricuspid Valve InsufficiencyAgedAged, 80 and overEchocardiographyFemaleFollow-Up StudiesHeart FailureHumansMalePrevalenceProspective StudiesSeverity of Illness IndexLead extractionRight-sided heart failureSurgeryTranscatheter edge-to-edge repairTricuspid valve

Identifiers

PMID42462158
PMCPMC13381786

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.