Evidence map›Paper›PMID 42462713›Full record

ArticleStem cell reports2026

Brain injury reactivates a developmental program driving genesis and integration of transient LGE-class interneurons.

G Nato, M Fogli, N Marichal, V Cerrato, G Turrini, V Proserpio, I Ghia, G Zanotto, I Molineris, M Bergami and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

G NatoNeuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; Department of Neurosciences "Rita Levi Montalcini", University of Turin, Turin, Italy.
M FogliNeuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; Department of Life Sciences and System Biology, University of Turin, Turin, Italy.
N MarichalCentre for Developmental Neurobiology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Institute of Physiological Chemistry, University Medical Center Johannes Gutenberg University, Mainz, Germany.
V CerratoNeuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; Department of Neurosciences "Rita Levi Montalcini", University of Turin, Turin, Italy.
G TurriniNeuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; Department of Neurosciences "Rita Levi Montalcini", University of Turin, Turin, Italy.
V ProserpioDepartment of Life Sciences and System Biology, University of Turin, Turin, Italy; Molecular Biotechnology Center "Guido Tarone", University of Turin, Turin, Italy.
I GhiaNeuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; Department of Life Sciences and System Biology, University of Turin, Turin, Italy.
G ZanottoNeuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; Department of Life Sciences and System Biology, University of Turin, Turin, Italy.
I MolinerisDepartment of Life Sciences and System Biology, University of Turin, Turin, Italy.
M BergamiCologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases, University of Cologne, Cologne, Germany; Center for Molecular Medicine, 50931 Cologne, Germany; Institute of Genetics, University of Cologne, Cologne, Germany; University of Cologne, Faculty of Medicine and University Hospital Cologne, Cologne, Germany.
S OlivieroDepartment of Life Sciences and System Biology, University of Turin, Turin, Italy; Molecular Biotechnology Center "Guido Tarone", University of Turin, Turin, Italy; Italian Institute for Genomic Medicine, Candiolo, Turin, Italy.
P PerettoNeuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; Department of Life Sciences and System Biology, University of Turin, Turin, Italy.
B BerningerCentre for Developmental Neurobiology, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Institute of Physiological Chemistry, University Medical Center Johannes Gutenberg University, Mainz, Germany; MRC Centre for Neurodevelopmental Disorders, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, UK; Focus Program Translational Neurosciences, Johannes Gutenberg University, Mainz, Germany.
A BuffoNeuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; Department of Neurosciences "Rita Levi Montalcini", University of Turin, Turin, Italy.
F LuzzatiNeuroscience Institute Cavalieri Ottolenghi, Orbassano, Turin, Italy; Department of Life Sciences and System Biology, University of Turin, Turin, Italy. Electronic address: federico.luzzati@unito.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Brain lesions can unlock latent neurogenic potential in parenchymal astrocytes, but the identity of their neuronal progeny has remained unclear. Here, we show that neurons generated by striatal astrocytes after excitotoxic lesions are transient, yet reach advanced morphological and functional maturation and integrate into cortico-striatal-thalamic circuits. Single-cell RNA-seq mapping onto an embryonic reference revealed these cells are not fated to adult striatal neuron types but belong to the LGE-MEIS2/PAX6 interneuron class. Reanalysis of neuroblasts from cortical and striatal astrocytes after Notch abrogation revealed shared commitment of rostral telencephalic astrocytes to this class. Public spatial transcriptomics datasets revealed these cells are widely distributed throughout the mouse telencephalon during embryonic and postnatal development. Thus, unlike other vertebrates in which adult telencephalic astroglia preserve the potential to generate resident, regionally appropriate neuronal types, homologous mammalian cells converge on a specific transient neuron class, possibly representing a reservoir for circuit plasticity in adult life.

Indexed as

InterneuronsNeurogenesisAnimalsAstrocytesCell DifferentiationGene Expression Regulation, DevelopmentalMiceNeural Stem CellsNeurodevelopmentPAX6 Transcription FactorTelencephalonPAX6 Transcription Factorastrocyte neural stem cell potentialcell fate specificationcircuit integrationcortico-striatal-thalamic circuitsdormant stem cellslateral ganglionic eminence interneuronsneuronal identityneurorepairpostnatal developmentreactive neurogenesis

Identifiers

PMID42462713
PMCPMC13476880

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.