SynthesisPediatric obesity2026
Precision Health Approaches in Primary Childhood Obesity Prevention: A Systematic Review of Tailored and Risk-Based Interventions.
Synthesis in Pediatric obesity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
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Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
backgroundPrecision health represents an emerging paradigm in public health that uses individualised risk profiles to guide targeted prevention strategies. In childhood obesity, early-life determinants-such as genetics, growth patterns, family behaviours and environmental exposures-can inform interventions tailored to the specific needs of high-risk populations. Traditional universal approaches have shown limited long-term effectiveness, highlighting the need for more personalised prevention models.
objectiveThis systematic review aimed to (1) evaluate the effectiveness of tailored and risk-based interventions for the primary prevention of childhood obesity in children aged 0-12 years, and (2) examine implementation characteristics and contextual factors influencing intervention outcomes.
methodsFollowing PRISMA 2020 guidelines, we searched six databases (PubMed, Embase, Web of Science, Scopus, PsycINFO and CINAHL). The protocol was registered on PROSPERO (CRD420251103591). Eligible studies included RCTs, quasi-experimental, or pilot studies targeting obesity prevention using tailored or risk-stratified approaches in children aged 0-12, reporting anthropometric or behavioural outcomes. Data extraction and quality appraisal were conducted independently by two reviewers, with synthesis via narrative and thematic methods.
resultsSixteen studies met inclusion criteria. Nine of 16 studies (56.3%) reported statistically significant reductions in BMI z-scores or obesity prevalence, with effect sizes ranging from -0.10 to -0.54 in BMI z-score units. Eleven studies (68.8%) observed significant improvements in dietary intake or physical activity behaviours. Culturally adapted, equity-focused interventions showed higher uptake and effectiveness. Key challenges included limited scalability, short follow-up periods and fidelity variability.
conclusionsTailored, risk-based interventions hold promise for reducing early obesity risk and improving health behaviours. Precision health strategies, especially those that are family-centred and culturally sensitive, warrant further longitudinal evaluation to enhance equity and impact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.