Evidence map›Paper›PMID 42463884›Full record

ArticleNature human behaviour2026

Association of traumatic experiences with depressive symptoms among LGBTQ+ population in China.

Jingli Yang, Yu Wang, Lei Liu, Junren Wang, Yueyao Xu, Shu Wen, Peipei Zhao, Peipei Du, Yumeng Wang, Xin Han and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature human behaviour, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jingli YangNational Center for Mental Disorders and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China.ORCID http://orcid.org/0000-0003-0773-494X
Yu WangMed-X Center for Informatics, Sichuan University, Chengdu, China.
Lei LiuMed-X Center for Informatics, Sichuan University, Chengdu, China.
Junren WangMed-X Center for Informatics, Sichuan University, Chengdu, China.
Yueyao XuMed-X Center for Informatics, Sichuan University, Chengdu, China.
Shu WenMed-X Center for Informatics, Sichuan University, Chengdu, China.
Peipei ZhaoState Key Laboratory of Reproductive Medicine and Offspring Health & National Vaccine Innovation Platform & Laboratory for Digital Intelligence & Health Governance & Department of Social Medicine and Implementation Science, School of Public Health, Nanjing Medical University, Nanjing, China.ORCID http://orcid.org/0000-0002-5399-3443
Peipei DuDepartment of Psychiatry, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Yumeng WangDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.ORCID http://orcid.org/0009-0009-4034-5728
Xin HanMental Health Center and National Center for Mental Disorders, West China Hospital, Sichuan University, Chengdu, China.
Brian J HallCenter for Global Health Equity, New York University Shanghai, Shanghai, China.ORCID http://orcid.org/0000-0001-9358-2377
Fang FangInstitute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-3310-6456
Xiaodong WangChengdu Tongle Health Counseling Service Center, Chengdu, China.
Dan WuState Key Laboratory of Reproductive Medicine and Offspring Health & National Vaccine Innovation Platform & Laboratory for Digital Intelligence & Health Governance & Department of Social Medicine and Implementation Science, School of Public Health, Nanjing Medical University, Nanjing, China. danwu@njmu.edu.cn.ORCID http://orcid.org/0000-0003-0415-5467
Huan SongNational Center for Mental Disorders and West China Biomedical Big Data Center, West China Hospital, Sichuan University, Chengdu, China. songhuan@wchscu.cn.ORCID http://orcid.org/0000-0003-3845-8079

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trauma is a major contributor to mental health disparities among LGBTQ+ individuals, yet evidence from non-Western contexts remains limited. Using baseline data from 8,384 participants in the TREASURE cohort in Chengdu, China, we examined associations between trauma exposure (adverse childhood experiences, lifetime trauma and LGBTQ+-related adversities) and depressive symptoms. Trauma exposure was highly prevalent (92.7%), particularly LGBTQ+-related adversities (87.3%). Depressive symptoms were observed in 30.2% of participants and were associated with trauma exposure (adjusted odds ratio = 11.00, 95% confidence interval, 7.39-16.39), exhibiting a dose-response relationship: each additional traumatic event is associated with 10% higher risk of depressive symptoms (95% confidence interval, 9-11%). Sequential mediation analysis suggested that unfavourable behavioural factors such as smoking (mediated proportions, 14.99-40.23%), lower social support (7.91-33.08%) and negative coping (1.79-37.66%) may mediate these associations. Despite limitations including non-representative, cross-sectional and self-reported data, our findings highlight that trauma exposure is ubiquitous and associated with depressive symptoms among Chinese LGBTQ+ individuals.

Indexed as

Adverse Childhood ExperiencesDepressionSexual and Gender MinoritiesAdaptation, PsychologicalAdultChinaCross-Sectional StudiesFemaleHumansMaleMiddle AgedPrevalenceSmokingSocial Support

Identifiers

PMID42463884

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.