ReviewMolecular genetics & genomic medicine2026
Knowledge Mapping of Alport Syndrome: A Bibliometric Analysis From 2000 to 2025.
Review in Molecular genetics & genomic medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlport syndrome (AS) is a multisystem hereditary disorder characterized by persistent hematuria, progressive renal insufficiency, sensorineural hearing loss, and ocular abnormalities. Its pathogenesis is mainly due to mutations in COL4A3, COL4A4, or COL4A5 genes encoding type IV collagen α chains, leading to glomerular dysfunction and end-stage renal disease. A systematic evaluation of its global research landscape is lacking, and bibliometric analysis can fill this gap.
methodsA comprehensive bibliometric analysis was conducted using Biblioshiny, VOSviewer, and CiteSpace. Data were extracted from the Web of Science Core Collection (2000-2025), with 1205 valid publications included. Multiple dimensions including annual output, citations, co-authorship, and keywords were analyzed.
resultsBibliometric analysis showed that AS-related annual publications had a consistent upward trend from 2000 to 2025. The 1205 included publications accumulated 34,314 citations, with the most cited being R. C. Wiggins' 2007 original study (622 citations). Co-authorship analysis identified Judy Savige as the most prolific author and the United States as the leading contributing country. Co-citation analysis mapped the field's intellectual structure, and keywords included "natural history," "IV collagen," and "identification" besides core terms "Alport syndrome" and "mutations".
conclusionGlobal interest in AS research has increased significantly. With academic exchanges and international cooperation, its pathogenesis mechanisms are gradually clarified. This bibliometric analysis identifies research hotspots and guides future directions, providing references for related research and clinical practice.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.