In one paragraphArticle in Stroke, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
12 authors.
Alexandra MorozovaCentre for Clinical Brain Sciences, Institute for Neuroscience and Cardiovascular Research, College of Medicine and Veterinary Medicine, The University of Edinburgh, United Kingdom (A. Morozova, M.C.V.H., R.D.C., H.C.W., A.M., J.M.W.).ORCID 0000-0003-3466-0886 Maria Del C Valdés HernándezCentre for Clinical Brain Sciences, Institute for Neuroscience and Cardiovascular Research, College of Medicine and Veterinary Medicine, The University of Edinburgh, United Kingdom (A. Morozova, M.C.V.H., R.D.C., H.C.W., A.M., J.M.W.).ORCID 0000-0003-2771-6546 Roberto Duarte CoelloCentre for Clinical Brain Sciences, Institute for Neuroscience and Cardiovascular Research, College of Medicine and Veterinary Medicine, The University of Edinburgh, United Kingdom (A. Morozova, M.C.V.H., R.D.C., H.C.W., A.M., J.M.W.).ORCID 0000-0003-2952-2163 Heather C WhalleyCentre for Clinical Brain Sciences, Institute for Neuroscience and Cardiovascular Research, College of Medicine and Veterinary Medicine, The University of Edinburgh, United Kingdom (A. Morozova, M.C.V.H., R.D.C., H.C.W., A.M., J.M.W.).ORCID 0000-0002-4505-8869 Andrew McIntoshCentre for Clinical Brain Sciences, Institute for Neuroscience and Cardiovascular Research, College of Medicine and Veterinary Medicine, The University of Edinburgh, United Kingdom (A. Morozova, M.C.V.H., R.D.C., H.C.W., A.M., J.M.W.).ORCID 0000-0002-0198-4588 Anca-Larisa Sandu GiuraniucScottish Imaging Network: A Platform for Scientific Excellence (SINAPSE, www.sinapse.ac.uk) (M.C.V.H., R.D.C., H.C.W., A.-L.S.G., G.D.W., C.J.M.N., J.D.S., J.A.M., A.D.M., J.M.W.).ORCID 0000-0002-5555-4129 Gordon D WaiterScottish Imaging Network: A Platform for Scientific Excellence (SINAPSE, www.sinapse.ac.uk) (M.C.V.H., R.D.C., H.C.W., A.-L.S.G., G.D.W., C.J.M.N., J.D.S., J.A.M., A.D.M., J.M.W.).ORCID 0000-0002-5313-9845 Christopher J McNeilScottish Imaging Network: A Platform for Scientific Excellence (SINAPSE, www.sinapse.ac.uk) (M.C.V.H., R.D.C., H.C.W., A.-L.S.G., G.D.W., C.J.M.N., J.D.S., J.A.M., A.D.M., J.M.W.).
J Douglas SteeleScottish Imaging Network: A Platform for Scientific Excellence (SINAPSE, www.sinapse.ac.uk) (M.C.V.H., R.D.C., H.C.W., A.-L.S.G., G.D.W., C.J.M.N., J.D.S., J.A.M., A.D.M., J.M.W.).ORCID 0000-0002-9822-8753 Jennifer A MacfarlaneScottish Imaging Network: A Platform for Scientific Excellence (SINAPSE, www.sinapse.ac.uk) (M.C.V.H., R.D.C., H.C.W., A.-L.S.G., G.D.W., C.J.M.N., J.D.S., J.A.M., A.D.M., J.M.W.).ORCID 0000-0002-1688-1653 Alison D MurrayScottish Imaging Network: A Platform for Scientific Excellence (SINAPSE, www.sinapse.ac.uk) (M.C.V.H., R.D.C., H.C.W., A.-L.S.G., G.D.W., C.J.M.N., J.D.S., J.A.M., A.D.M., J.M.W.).ORCID 0000-0003-4915-4847 Joanna M WardlawCentre for Clinical Brain Sciences, Institute for Neuroscience and Cardiovascular Research, College of Medicine and Veterinary Medicine, The University of Edinburgh, United Kingdom (A. Morozova, M.C.V.H., R.D.C., H.C.W., A.M., J.M.W.).ORCID 0000-0002-9812-6642 Funding
Wellcome Trust
6 · The paper itselfAbstract
backgroundBrain perivascular spaces (PVS) are emerging magnetic resonance imaging markers of microvascular function and waste metabolite clearance. Although PVS enlargement has been linked to aging and vascular risk, it remains unclear whether PVS morphometry reflects shared familial microvascular characteristics and how these are shaped by individual vascular, physiological, and neuropsychiatric factors. We investigated whether PVS morphometry captures these familial characteristics in addition to individual determinants.
methodsWe analyzed 1183 participants from the Stratifying Depression and Resilience Longitudinally family-based cohort, including 324 individuals with first-degree relatives. Automated magnetic resonance imaging segmentation quantified PVS volume, count, density, and median length in the centrum semiovale and basal ganglia. Linear mixed-effects models assessed associations with age, hypertension, hair cortisol, depressive symptom scores, and hand grip strength while accounting for familial clustering.
resultsIn 1050 individuals (59.5% female; mean age, 59.3±10.1 years), PVS burden increased with age (PVSvolume%ROI, β=0.18 [95% CI, 0.11-0.26];
conclusionsPVS morphometry reflects shared familial microvascular phenotypes and neuropsychiatric influences beyond hypertension, highlighting both familial and individual determinants of PVS burden and morphology. These findings support PVS morphometry as a neuroimaging marker of cerebral microvascular health.
Indexed as
BrainDepressionGlymphatic SystemMicrovesselsAdultAgedCohort StudiesFemaleHand StrengthHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle Ageddepressionhypertensionmagnetic resonance imagingneuroimagingperivascular spacesstress
Identifiers
PMID42464807
PMCPMC13506202
What Socratic holds
Textmetadata
Read underepoch 390