ArticleAmerican journal of cancer research2026
Vitamin B1 suppresses liver cancer growth and restores tumor microcirculation.
Article in American journal of cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Inadequate perfusion and hypoxia constitute the primary characteristics of tumor vasculature and drive malignant progression. Strategies aiming at alleviating hypoxia and enhancing blood perfusion may potentiate chemotherapy and immunotherapy, thereby restraining tumor growth. Vitamin B1 (VitB1), an essential coenzyme for multiple metabolic enzymes, plays a crucial role in cellular energy metabolism and in maintaining the balance between glycolysis and the tricarboxylic acid cycle. However, whether the tumor-suppressive effects of VitB1 are associated with modulation of tumor microcirculation remains unclear. This study aimed to evaluate the anti-tumor effects of VitB1 and to investigate the potential relationship with microcirculatory changes in liver cancer. VitB1 inhibited tumor-cell proliferation
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