SynthesisFrontiers in medicine2026
Effects of different negative pressure wound therapy modes on wound healing: a systematic review.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Introduction: Negative pressure wound therapy (NPWT) has been widely used in wound care, yet the optimal application mode-continuous, intermittent, or dynamic-remains unclear. This systematic review aimed to compare the effects of different NPWT modes on wound-healing-related outcomes and to provide evidence for mode selection in clinical practice. Methods: Following PRISMA guidelines, a systematic search was conducted across 11 databases-PubMed, MEDLINE, EMBASE, ProQuest, CINAHL, Web of Science, CENTRAL, CNKI, CBM, VIP, and WANFANG-from 1997 to 2024. Results: Ten clinical studies and 15 animal studies were included. Clinical studies involved both acute and chronic wounds, whereas animal studies mainly used full-thickness skin wound models. Reported outcomes included clinical efficacy, wound microenvironment, and molecular-level changes. Current evidence suggests that continuous, intermittent, and dynamic NPWT may influence wound healing in different ways. Compared with continuous NPWT, the two non-continuous modes-intermittent NPWT and dynamic NPWT-appeared to offer potential advantages in selected outcomes, particularly with respect to wound healing speed, tissue perfusion, and granulation-related responses. Discussion: Due to substantial heterogeneity in wound types, parameter settings, outcome measures, and study designs, the available evidence remains insufficient to establish a definitive ranking among NPWT modes or to determine optimal treatment parameters. Future research should focus on large-scale, high-quality, multicenter studies with refined wound-type stratification and greater standardization of pressure parameters and outcome measures to clarify the mode-specific effects, indications, and parameter settings of NPWT.
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