Evidence map›Paper›PMID 42465301›Full record

ArticlebioRxiv : the preprint server for biology2026

The role of electrostatic interactions in the phase separation of HP1α and its protein binding partners.

Cheenou Her, Rushabh Bhakta, Tonkhla Dankul, Tien M Phan, Lannah S Abasi, Jeetain Mittal, Galia T Debelouchina

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Cheenou HerDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Rushabh BhaktaDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Tonkhla DankulDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Tien M PhanArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, USA.ORCID 0000-0002-8608-7359
Lannah S AbasiDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.
Jeetain MittalArtie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, TX, USA.
Galia T DebelouchinaDepartment of Chemistry and Biochemistry, University of California San Diego, La Jolla, CA, USA.ORCID 0000-0001-6775-9415

Funding

Molecular Biophysics Training Grant at UC San DiegoT32GM139795 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Galia Debelouchina, ELIZABETH A. KOMIVES · 2021 to 2026
$3.0M
Structural biology of chromatin in vitro and in cellsR35GM138382 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Galia Debelouchina · 2020 to 2026
$2.8M
Multiscale Computational Models to Investigate the Role of Phase Separation in BiologyR35GM153388 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI Jeetain Mittal · 2024 to 2026
$1.3M
Multiscale Computational Models of Heterochromatin Phase SeparationK99GM159055 · NIGMS · TEXAS ENGINEERING EXPERIMENT STATION · PI Tien Minh Phan · 2026 to 2026
$135k
NIGMS NIH HHS K99 GM159055NIGMS NIH HHS R35 GM138382NIGMS NIH HHS R35 GM153388NIGMS NIH HHS T32 GM139795
6 · The paper itself

Abstract

Heterochromatin protein 1α (HP1α) is an intrinsic component of heterochromatin domains where it is involved in a diverse set of functions including heterochromatin spreading and organization, chromatin compaction and transcriptional silencing. It has been suggested that HP1α functions through a phase separation mechanism, a process that has been observed

Identifiers

PMID42465301
PMCPMC13371100

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.