Evidence map›Paper›PMID 42465461›Full record

ArticlebioRxiv : the preprint server for biology2026

Discovery of non-nucleoside inhibitors of the enterovirus D68 3D polymerase through crystallographic fragment and high-throughput biochemical screening.

Iman Biswas, Qinghui Wang, Jack T McCann, Egor P Tchesnokov, Linh Nguyen, Manisha Saini, Jocelyn Cantero, Jezrael Lafuente Revalde, Matthias Götte, Adam R Renslo and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Iman BiswasCenter for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, NJ 08854, USA.ORCID 0000-0001-8686-9687
Qinghui WangDepartment of Pharmaceutical Chemistry, UCSF, CA 94158, USA.ORCID 0000-0002-1223-8193
Jack T McCannDepartment of Pharmaceutical Chemistry, UCSF, CA 94158, USA.ORCID 0000-0002-8812-829X
Egor P TchesnokovDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.ORCID 0000-0003-1698-2961
Linh NguyenDepartment of Pharmaceutical Chemistry, UCSF, CA 94158, USA.
Manisha SainiCenter for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, NJ 08854, USA.ORCID 0000-0003-2242-3218
Jocelyn CanteroDepartment of Pharmaceutical Chemistry, UCSF, CA 94158, USA.
Jezrael Lafuente RevaldeDepartment of Pharmaceutical Chemistry, UCSF, CA 94158, USA.ORCID 0000-0002-8794-6784
Matthias GötteDepartment of Medical Microbiology and Immunology, University of Alberta, Edmonton, Alberta T6G 2E1, Canada.ORCID 0000-0001-6213-5806
Adam R RensloDepartment of Pharmaceutical Chemistry, UCSF, CA 94158, USA.
R Jeffrey NeitzDepartment of Pharmaceutical Chemistry, UCSF, CA 94158, USA.ORCID 0000-0002-2247-9345
Michelle R ArkinDepartment of Pharmaceutical Chemistry, UCSF, CA 94158, USA.ORCID 0000-0002-9366-6770
Eddy ArnoldCenter for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, NJ 08854, USA.ORCID 0000-0003-2612-9622
Francesc Xavier RuizCenter for Advanced Biotechnology and Medicine, Rutgers, the State University of New Jersey, Piscataway, NJ 08854, USA.ORCID 0000-0002-0457-0030

Funding

Targeting Viroporins and Coronavirus M ProteinU19AI171110 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Nevan J Krogan · 2022 to 2026
$103.4M
NIAID NIH HHS U19 AI171110
6 · The paper itself

Abstract

Enterovirus D68 (EV-D68) is a non-polio picornavirus that has caused increasing rates of severe respiratory illness and acute flaccid myelitis in children worldwide this century. There are no approved vaccines or antivirals for EV-D68. Thus, we conducted a crystallographic fragment screening (CFS) and a high-throughput screening (HTS) biochemical assay against the EV-D68 RNA-dependent RNA polymerase 3D (3D

Identifiers

PMID42465461
PMCPMC13370946

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.