Evidence map›Paper›PMID 42465484›Full record

ArticlebioRxiv : the preprint server for biology2026

Fetal sex shapes placental inflammatory responses to extracellular mitochondrial DNA.

Reneé de Nazaré Oliveira da Silva, Nataliia Hula, Desirae Escalera, Leslie Lopez, Gabrielle Kelly, Isabelle K Gorham, Megan Rowe, Contessa A Ricci, Ciprian Gheorghe, Nicole R Phillips and 1 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Reneé de Nazaré Oliveira da SilvaLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University, Loma Linda, California, USA.
Nataliia HulaLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University, Loma Linda, California, USA.
Desirae EscaleraLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University, Loma Linda, California, USA.
Leslie LopezLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University, Loma Linda, California, USA.
Gabrielle KellyLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University, Loma Linda, California, USA.
Isabelle K GorhamDepartment of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Megan RoweDepartment of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Contessa A RicciInstitute for Research and Education to Advance Community Health (IREACH), College of Nursing, Elson S. Floyd College of Medicine, Washington State University, USA.
Ciprian GheorgheLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University, Loma Linda, California, USA.
Nicole R PhillipsDepartment of Microbiology, Immunology, and Genetics, University of North Texas Health Science Center, Fort Worth, Texas, USA.
Styliani GoulopoulouLawrence D. Longo, MD Center for Perinatal Biology, Department of Basic Sciences, Loma Linda University, Loma Linda, California, USA.ORCID 0000-0001-7636-8256

Funding

Preeclampsia and pre-clinical stages of maternal vascular dementiaR01HL146562 · NHLBI · UNIVERSITY OF NORTH TEXAS HLTH SCI CTR · PI GOULOPOULOU, STYLIANI · 2020 to 2024
$2.9M
Relationships Between Environments and Pregnancy via Traditional FoodsF32MD019202 · NIMHD · WASHINGTON STATE UNIVERSITY · PI Contessa Ricci · 2023 to 2026
$245k
NHLBI NIH HHS R01 HL146562NIMHD NIH HHS F32 MD019202
6 · The paper itself

Abstract

Aberrant changes in circulating cell-free mitochondrial DNA (ccf-mtDNA) across gestation are associated with adverse pregnancy outcomes. Given the inflammatory properties of ccf-mtDNA via pattern recognition receptors such as Toll-like receptor 9 (TLR9), we hypothesized that extracellular mtDNA induces placental inflammation via TLR9 signaling and that this response differs by fetal sex. Pregnant Sprague-Dawley rats were treated intravenously with purified mtDNA (300 μg/kg), nuclear DNA (nDNA), saline, and/or the TLR9 antagonist ODN2088 across five studies. Placental responses were evaluated 4 h (Studies 1-3) and 24 h (Study 4) post-treatment; pregnancy and neonatal outcomes were assessed at delivery (Study 5). Exposure to mtDNA, but not nDNA, increased placental

Indexed as

inflammationmitochondrial DNAplacentasex differences

Identifiers

PMID42465484
PMCPMC13370408

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.