Evidence map›Paper›PMID 42465485›Full record

ArticlebioRxiv : the preprint server for biology2026

Patient-derived tau-seeded human neuronal chimeras recapitulate mature Alzheimer's tau pathology and uncover human-specific neuronal vulnerability.

Yanru Ji, Purba Mandal, Jiahui Liu, Wen Hu, Bryce David Colón, Changlin Wan, Raymond W Pan, Dongkai Guo, Lijia Zhang, Xingjian Gu and 9 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Yanru JiDepartment of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
Purba MandalSchool of Health Science, Purdue University, West Lafayette, IN 47907, USA.
Jiahui LiuDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Wen HuDepartment of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA.
Bryce David ColónBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN, 47907, USA.
Changlin WanDepartment of Biological Engineering, Oregon Health & Science University, Portland, OR 997239, USA.
Raymond W PanDepartment of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
Dongkai GuoDepartment of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
Lijia ZhangDepartment of Comparative Pathobiology, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana 47907, USA.
Xingjian GuDepartment of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.
Yang YangBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN, 47907, USA.
Kun HuangDepartment of Biostatistics and Health Data Science, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Riyi ShiWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Chao QiDepartment of Biophysics, School of Basic Medical Sciences and Key Laboratory for Neuroscience, Ministry of Education/National Health Commission of the People's Republic of China, Peking University, Beijing 100080, China.
Chongli YuanDavidson School of Chemical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Jean-Christophe RochetBorch Department of Medicinal Chemistry and Molecular Pharmacology, College of Pharmacy, Purdue University, West Lafayette, IN, 47907, USA.
Priyanka BaloniSchool of Health Science, Purdue University, West Lafayette, IN 47907, USA.
Fei LiuDepartment of Neurochemistry, Inge Grundke-Iqbal Research Floor, New York State Institute for Basic Research in Developmental Disabilities, 1050 Forest Hill Road, Staten Island, NY 10314, USA.
Ranjie XuDepartment of Basic Medical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, IN 47907.ORCID 0000-0001-9401-6430

Funding

Elucidate Gene-environmental interactions employed by Pb in promoting ADRD in aging brainsU01AG088662 · NIA · PURDUE UNIVERSITY · PI Ranjie Xu, Chongli Yuan · 2024 to 2026
$2.3M
Generative Peptide Drug Design for AD/ADRDR01AG098151 · NIA · PURDUE UNIVERSITY · PI Jianing Li, JEAN-CHRISTOPHE ROCHET · 2026 to 2026
$1.3M
Develop a human-mouse chimeric brain model for studying tau pathology in human neuron in vivoR21NS140907 · NINDS · PURDUE UNIVERSITY · PI XU, RANJIE · 2024 to 2025
$432k
Optical Sensing of the Spread of Alpha-Synuclein Aggregates in Models of Parkinson's Disease and Related DementiasR21NS135424 · NINDS · PURDUE UNIVERSITY · PI WEBB, KEVIN J · 2024 to 2024
$406k
NIA NIH HHS R01 AG098151NIA NIH HHS U01 AG088662NINDS NIH HHS R21 NS135424NINDS NIH HHS R21 NS140907
6 · The paper itself

Abstract

Tau pathology is a central hallmark of Alzheimer's disease (AD) and strongly correlates with cognitive decline, yet the development of tau-targeted therapies has been hindered by the inability of existing models to capture human-specific disease features, particularly the mature forms of AD tau pathology. Moreover, species-specific mechanisms underlying tau pathology remain poorly understood. Here, we establish a patient-derived tau-seeded human neuronal chimera model by transplanting human pluripotent stem cell (hPSC)-derived neural progenitor cells into neonatal mouse brains, followed by intracerebral injection of pathological tau seeds from postmortem AD brains. Human neurons matured

Identifiers

PMID42465485
PMCPMC13370950

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.