ArticlebioRxiv : the preprint server for biology2026
BxbI-mediated insertion of a 77kb human RET sensitive haplotype into the mouse genome to generate a humanized model of Hirschsprung disease.
Ryan D Fine, Benjamin E Low, Jarod Rollins, Jon M Laurent, Michael V Wiles, Aamir Zuberi, Jef D Boeke, Aravinda Chakravarti
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
8 authors.
Benjamin E LowTechnology Evaluation and Development, The Jackson Laboratory, Bar Harbor, ME.
Jarod RollinsTechnology Evaluation and Development, The Jackson Laboratory, Bar Harbor, ME.
Jon M LaurentInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY.
Michael V WilesTechnology Evaluation and Development, The Jackson Laboratory, Bar Harbor, ME.
Aamir ZuberiTechnology Evaluation and Development, The Jackson Laboratory, Bar Harbor, ME.
Jef D BoekeInstitute for Systems Genetics and Department of Biochemistry and Molecular Pharmacology, NYU Grossman School of Medicine, New York, NY.
Aravinda ChakravartiCenter for Human Genetics and Genomics, NYU Grossman School of Medicine, New York, NY.
Funding
Vaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1MSupplement for Center for Synthetic Regulatory Genomics: Building CACNA1C alleles associated with Neuropsychiatric DisordersRM1HG009491 · NHGRI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Jef D BOEKE · 2018 to 2026
$20.9MGenetic Analysis of Hirschsprung Disease - RenewalR01HD028088 · NICHD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CHAKRAVARTI, ARAVINDA · 1991 to 2024
$6.2MGenetic Analysis of Hirschsprung DiseaseR37HD028088 · NICHD · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CHAKRAVARTI, ARAVINDA · 2010 to 2019
$6.2MSite-specific Integration of Large (10-100 kb) DNA Constructs into the Mouse Genome and Human Induced Pluripotent Stem Cells Using the Cas9-Bxb1 Integrase ToolboxR01CA265978 · NCI · JACKSON LABORATORY · PI Vishnu Hosur · 2022 to 2026
$3.2MNCI NIH HHS P30 CA016087NCI NIH HHS R01 CA265978NHGRI NIH HHS RM1 HG009491NICHD NIH HHS R01 HD028088NICHD NIH HHS R37 HD028088
6 · The paper itselfAbstract
Hirschsprung disease (HSCR) is a complex developmental disorder of the enteric nervous system, primarily driven by regulatory variants within enhancer elements of the
Indexed as
Humanized geneMouseRETSyntheticYeast
Identifiers
PMID42465522
PMCPMC13371033
What Socratic holds
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