ReviewConsortium psychiatricum2026
Small Extracellular Vesicles in Alcohol Use Disorders: A Scoping Review.
Review in Consortium psychiatricum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Extracellular Vesicle Phenotypic Trajectories During Alcohol Withdrawal Treatment.International journal of molecular sciences · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlcohol consumption is one of the most significant global public health challenges. The pathophysiology of alcohol use disorder remains only partially elucidated, and direct biomarkers for this disorder have yet to be identified. Some studies have investigated the profiles of small extracellular vesicles (sEVs) in different bodily fluids. However, the findings across these studies are heterogeneous, and the methodological quality of these studies has not been systematically assessed.
aimTo summarize the results of studies examining the sEVs' profiles in alcohol use disorders.
methodsThe review included original research articles that explored the sEVs' profiles in alcohol use disorders. The MEDLINE (for studies published up to November 2025) and Scopus (for studies published up to January 10, 2026) were searched. The analysis of the included studies was conducted using a descriptive evidence synthesis approach based on the categories of lipid profile, protein profile, and signaling molecules. The methodological quality of the studies was assessed using the Newcastle-Ottawa Scale (NOS) adapted for extracellular vesicle research.
resultsTen studies were included. All studies employed a cross-sectional design, were conducted in small cohorts, and included patients with acute and chronic alcohol intoxication, as well as those with alcohol use disorder. Significant differences in the sEVs' profiles were identified in individuals with alcohol use disorders compared to healthy controls. These differences encompassed modifications in lipid and protein profiles, decreased expression of hsa-miR-144-5p, hsa-miR-182-5p, hsa-miR-142-5p, hsa-miR-7-5p, hsa-miR-15b-5p, and hsa-circ-0004771, an increased expression of miR-30a-5p and miR-194-5p, as well as alterations in inflammatory response parameters. The majority of these differences were related to the regulation of inflammation.
conclusionIn alcohol use disorders, sEVs differ in lipid and protein profiles as well as in microRNA expression. New studies are needed to investigate the impact of sEVs on the regulation of systemic inflammation in alcohol use disorders using a prospective design with repeated measurements of specific sEV characteristics.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.