ArticleFrontiers in bioengineering and biotechnology2026
Multi-cell-component cartilage organoids simulate intercellular microstress, hypoxic microenvironment, and chondrocyte-endothelial crosstalk
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: In cartilage-related studies, the existing Methods: Organoids were constructed using SW1353 chondrocytes and HMEC-1 endothelial cell lines within low-adhesion grid microchambers. A monosodium iodoacetate (MIA)-induced OA model was developed. Histological and immunofluorescence analyses of the organoids were conducted to examine markers of matrix metabolism, cytoskeletal and intercellular microstress, hypoxic microenvironment, and chondrocyte -endothelial crosstalk. The organoid features were compared with those of standard 2D cell cultures and Results: The multi-cell-component organoids successfully recapitulated critical Discussion: The multi-cell-component cartilage organoids constructed from tumor-derived cell lines using low-adhesion grid microchambers partially simulated intercellular microstress, hypoxic microenvironment, and chondrocyte -endothelial crosstalk, which was similar to that observed in cartilages in vivo. These organoids provide a new strategy for conducting cartilage-related studies
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.