Evidence map›Paper›PMID 42465693›Full record

ArticleGut microbiology2026

From microbes to milestones: Gut bacterial abundances and functional pathways associate with neurodevelopment following preterm birth.

Kadi Vaher, Aisling Kenny, Paula Lusarreta Parga, Lorena Jiménez-Sánchez, Helen Turner, Rebekah Smikle, Amy Corrigan, Hilary Cruickshank, Magda Rudnicka, Sue Fletcher-Watson and 2 more

Abstract read
In one paragraph

Article in Gut microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Kadi VaherCentre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom.
Aisling KennyCentre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom.
Paula Lusarreta PargaCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom.
Lorena Jiménez-SánchezCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Helen TurnerCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Rebekah SmikleCentre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom.
Amy CorriganCentre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom.
Hilary CruickshankSimpson Centre for Reproductive Health, Royal Infirmary Edinburgh, Edinburgh, United Kingdom.
Magda RudnickaSimpson Centre for Reproductive Health, Royal Infirmary Edinburgh, Edinburgh, United Kingdom.
Sue Fletcher-WatsonCentre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, United Kingdom.
Debby BogaertCentre for Inflammation Research, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom.
James P BoardmanCentre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The early life gut microbiome has been identified as a potential driver of neurocognitive development. Evidence for this relationship in preterm children, who are at increased risk of both gut microbiome disruptions and neurodevelopmental impairment, is scarce. In a sample of 73 very preterm infants drawn from a prospective birth cohort, we assessed associations between the neonatal gut microbiome and neurodevelopmental outcomes at 9 months and 2 years. The gut microbiome taxonomic and functional profiles were obtained from stool samples collected prior to NICU discharge using shotgun metagenomics. Neurodevelopment was assessed using a battery of outcome measures. We took a consensus-based analytic approach, applying several different methods to investigate microbiome-outcome relationships and focussing on results which were consistently significant across methods. We found the most robust evidence for associations between the abundances of several gut bacterial species and measures related to autistic traits (e.g.

Indexed as

Autistic traitsExecutive functioningGut microbiomeMetagenomicsNeurodevelopmentPretermTemperament

Identifiers

PMID42465693
PMCPMC13375144

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.