ArticlemedRxiv : the preprint server for health sciences2026
Integrating multi-ancestry common and rare variant mapping accelerates therapeutic target discovery.
Nobuyuki Enzan, Sean J Jurgens, Seung Hoan Choi, Tetsushi Nakao, Satoshi Koyama, Patrick T Ellinor
Abstract readPreprint
In one paragraphArticle in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
6 authors.
Nobuyuki EnzanCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-3899-4405 Sean J JurgensCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-1605-9782 Seung Hoan ChoiCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Tetsushi NakaoCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Satoshi KoyamaCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-9286-0360 Patrick T EllinorCardiovascular Disease Initiative, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Funding
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6MUsing Electrocardiogram Genetics to Inform Arrhythmia RiskR01HL157635 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS, MIRSHAHI, TOORAJ · 2022 to 2025
$2.9MMentoring in Arrhythmia ResearchK24HL105780 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2011 to 2020
$1.2MUsing genomic modifiers to mechanistically link clonal hematopoiesis of indeterminate potential penetrance to coronary artery diseaseR00HL165024 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI Tetsushi Nakao · 2026 to 2026
$249kWhole genome sequence interpretation for lipids to discover new genes and mechanisms for coronary artery diseaseR00HL169733 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Satoshi Koyama · 2026 to 2026
$249kNHLBI NIH HHS K24 HL105780NHLBI NIH HHS R00 HL165024NHLBI NIH HHS R00 HL169733NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL157635
6 · The paper itselfAbstract
Integrating human genetics into therapeutic discovery accelerates drug development. However, ancestral biases in historical cohorts have left critical functional variation largely uncharted. Here, we leverage the diverse NIH
Identifiers
PMID42465895
PMCPMC13370553
What Socratic holds
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