Evidence map›Paper›PMID 42465905›Full record

ArticlemedRxiv : the preprint server for health sciences2026

Anti-CAR Immunity Drives Acquired Therapeutic Resistance to GD2-CAR T Cell Therapy in Diffuse Midline Glioma.

Yiyun Chen, Kevin Reynolds, Maximilian R A Koch, Camille F Petrakian, Zinaida Good, Sean Yamada-Hunter, Elena Sotillo, Kun-Wei Song, Jasia Mahdi, Robbie Majzner and 40 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in medRxiv : the preprint server for health sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

50 authors.

Yiyun ChenStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Kevin ReynoldsStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Maximilian R A KochStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Camille F PetrakianDepartment of Chemistry, Stanford University, Stanford, CA USA.
Zinaida GoodStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Sean Yamada-HunterStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Elena SotilloStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Kun-Wei SongStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Jasia MahdiStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Robbie MajznerStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Moksha H DesaiStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Ying-Wen HuangStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Hossein DaghaghStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Zachary J EhlingerStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Nadya IswariStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Chiara SabattiDivision of Biomedical Data Science, Department of Medicine, Stanford University, Stanford, CA USA.
Christina BaggottDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA USA.
Skyler P RietbergStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Kelvin C MoStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Kristin C Y TsuiStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Mark P HamiltonStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Emily EgelerStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Jennifer MoonDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA USA.
Courtney EricksonDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA USA.
Ashley JacobsDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA USA.
Allison K DuhDepartment of Neurosurgery, Stanford University, Stanford, CA USA.
Barbara BeebeStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Casey CarrStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Michelle FujimotoStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Michael KunickiStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Alexandria S LimStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Amy LiStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Annie K BrownStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Adam KuoStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Aanchal KaurDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA USA.
Smriti R SoundaranayagiDivision of Pediatric Hematology/Oncology/Stem Cell Transplant and Regenerative Medicine, Department of Pediatrics, Stanford University, Stanford, CA USA.
Snehit PrabhuStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Gerald GrantDepartment of Neurosurgery, Stanford University, Stanford, CA USA.
Laura M ProloDepartment of Neurosurgery, Stanford University, Stanford, CA USA.
Cynthia CampenDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA USA.
Sonia PartapDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA USA.
Kara L DavisStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Steven A FeldmanStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Ramya TunuguntlaStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Jennifer R CochranDepartment of Bioengineering, Stanford University, Stanford, CA USA.
Bita SahafStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Sabine HeitzenederStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Michelle MonjeStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Sneha RamakrishnaStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.
Crystal MackallStanford Center for Cancer Cell Therapy, Stanford Cancer Institute, Stanford University, Stanford, CA.

Funding

Translational Oncology Research Program (Project-005)P30CA124435 · NCI · STANFORD UNIVERSITY · PI MICHAEL KENNEY · 2007 to 2026
$71.4M
Stanford Center for Clinical and Translational Research and EducationUM1TR004921 · NCATS · STANFORD UNIVERSITY · PI MANISHA DESAI, DEAN W FELSHER · 2024 to 2026
$30.1M
Multimodal AI modeling of T cell therapies to predict patient response and nominate advanced cell design strategiesOT2OD038101 · OD · STANFORD UNIVERSITY · PI Olivier Gevaert, Crystal Mackall · 2025 to 2026
$4.2M
Developing Safe and Effective GD2-CAR T Cell Therapy for Diffuse Midline GliomasR01CA263500 · NCI · STANFORD UNIVERSITY · PI MACKALL, CRYSTAL, MONJE-DEISSEROTH, MICHELLE · 2021 to 2025
$3.3M
Next Generation Immunotherapies for Pediatric CancersR35CA283888 · NCI · STANFORD UNIVERSITY · PI Crystal Mackall · 2024 to 2026
$2.8M
NCATS NIH HHS UM1 TR004921NCI NIH HHS P30 CA124435NCI NIH HHS R01 CA263500NCI NIH HHS R35 CA283888NIH HHS OT2 OD038101
6 · The paper itself

Abstract

GD2-CAR T cell therapy has demonstrated clinical benefit in patients with H3K27M

Identifiers

PMID42465905
PMCPMC13370534

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.