Evidence map›Paper›PMID 42466067›Full record

ArticleNAR genomics and bioinformatics2026

The challenges of single cell transcriptomics on difficult human tissue: the placenta.

Theodoros Xenakis, George T Hall, Jose J Moreno-Villena, Sara L Hillman, Yara E Sanchez-Corrales, Sergi Castellano

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NAR genomics and bioinformatics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Insights into the maternal-fetal interface from spatial multi-omics.Frontiers in cell and developmental biology · 2026
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Theodoros XenakisGenetics and Genomic Medicine Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, London WC1N 1DZ, United Kingdom.ORCID https://orcid.org/0000-0003-3682-8873
George T HallGenetics and Genomic Medicine Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, London WC1N 1DZ, United Kingdom.
Jose J Moreno-VillenaGenetics and Genomic Medicine Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, London WC1N 1DZ, United Kingdom.
Sara L HillmanFetal Medicine Unit, University College London Hospitals (UCLH) NHS Foundation Trust, London NW1 2BU, United Kingdom.
Yara E Sanchez-CorralesGenetics and Genomic Medicine Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, London WC1N 1DZ, United Kingdom.
Sergi CastellanoGenetics and Genomic Medicine Research & Teaching Department, UCL Great Ormond Street Institute of Child Health, London WC1N 1DZ, United Kingdom.ORCID https://orcid.org/0000-0002-5819-4210

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Demand for the application of single cell transcriptomics on difficult tissues, processed and stored in disparate conditions, has led to the development of various single cell modalities. We focus on the placenta, a challenging tissue to transcriptomically interrogate due to senescence, intermittent hypoxia, high levels of RNase activity and tissue trauma at delivery. We performed single cell and nuclei transcriptomics on two samples with probe-based and native molecule transcript capture, droplet-based and

Indexed as

Gene Expression ProfilingPlacentaSingle-Cell AnalysisTranscriptomeFemaleHumansPregnancySingle-Cell Gene Expression Analysis

Identifiers

PMID42466067
PMCPMC13373321

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.