ArticleResearch square2026
Blunted modulation of hierarchical brain organization in opioid use disorder.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Authors and funding
15 authors.
Funding
Abstract
Opioid use disorder (OUD) is associated with persistent catecholaminergic dysfunction, but its impact on large-scale cortical organization remains unclear. We used pharmacological resting-state fMRI and functional gradient mapping to test whether OUD alters catecholaminergic modulation of cortical hierarchy. Fifty-three individuals with OUD and 40 healthy controls underwent resting-state fMRI after placebo and methylphenidate. Under placebo, principal and secondary cortical gradients showed canonical organization with no group differences. In controls, methylphenidate compressed the dynamic range of the principal gradient while preserving its spatial topology, indicating state-dependent modulation of the unimodal-transmodal hierarchy. This response was attenuated in OUD and further reduced among participants receiving methadone or buprenorphine. Methylphenidate improved visual attention in controls but not OUD, and gradient modulation predicted attentional benefit only in controls. Gradient features also predicted years of opioid use. These findings identify blunted catecholaminergic modulation of cortical hierarchy as a clinically relevant systems-level feature of OUD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.