Evidence map›Paper›PMID 42466552›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Chessboard Microneedle Array for Inflammation Regulation via Spatiotemporally Controlled Drug Delivery.

Yechun Jiang, Yongqi Gou, Hui Shen, Yidie Wang, Weinan Zhang, Yayun Wu, Litao Liu, Shu Fang, Ming Hu, Wanni Wang and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yechun JiangSchool of Pharmacy, Anhui Medical University, Hefei, Anhui, P.R. China.
Yongqi GouSchool of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, P. R. China.
Hui ShenSchool of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, P. R. China.
Yidie WangSchool of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, P. R. China.
Weinan ZhangSchool of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, P. R. China.
Yayun WuDepartment of Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, P. R. China.
Litao LiuSchool of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, P. R. China.
Shu FangSchool of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, P. R. China.
Ming HuSchool of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, P. R. China.
Wanni WangSchool of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, P. R. China.
Lingling XuSchool of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, P. R. China.
Haisheng QianSchool of Biomedical Engineering, Anhui Provincial Institute of Translational Medicine, Anhui Medical University, Hefei, Anhui, P. R. China.

Funding

National Natural Science Foundation of China 22405009National Natural Science Foundation of China 82572403
6 · The paper itself

Abstract

Excessive production of reactive oxygen species during photodynamic therapy (PDT) can exacerbate inflammation at the infection site and increase the risk of tumor metastasis, thereby posing significant challenges to treatment efficacy. In this study, a chessboard-structured microneedle patch (HPC@PCN CMN) was designed using a micromolding technique. This design spatially separates and encapsulates photosensitizers and antioxidants within distinct fast- and sustained-release microneedle systems, respectively, thereby achieving spatiotemporally ordered control of PDT and anti-inflammatory treatment. Additionally, by adjusting the crosslinking degree of hyaluronic acid, the release rate of antioxidant drugs can be regulated, which facilitates a prolonged anti-inflammatory effect. The results indicate that the anti-inflammatory process of HPC@PCN CMN can alleviate inflammation by inhibiting the ATP-P2RX4 pathway, demonstrating promising efficacy in the treatment of acne and melanoma. Overall, the developed chessboard microneedle platform is programmable, enabling not only the sequential regulation of oxidation-antioxidation but also the potential for broader applications in drug-delivery scenarios.

Indexed as

Anti-Inflammatory AgentsDrug Delivery SystemsInflammationNeedlesAcne VulgarisAnimalsAntioxidantsHumansHyaluronic AcidMiceMicroneedle Drug DeliveryPhotochemotherapyPhotosensitizing AgentsAnti-Inflammatory AgentsAntioxidantsHyaluronic AcidPhotosensitizing Agentsacneinflammationmelanomamicroneedlephotodynamic therapy

Identifiers

PMID42466552
PMCPMC13508722

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.