ReviewMolecular biology reports2026
Combination keratinocytes and fibroblasts cell-based therapy in wound healing: a literature review.
Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin grafting, a conventional treatment for wound management, is associated with significant limitations including donor-site morbidity, scarring, incomplete functional restoration, and limited efficacy in extensive or chronic wounds. Cell-based therapies, especially those involving combination therapy of keratinocytes and fibroblast, are an emerging and promising alternative. This review discusses the biological roles of keratinocytes and fibroblasts in skin homeostasis and wound repair, focusing on their crosstalk that regulate inflammation, extracellular matrix remodeling, angiogenesis, and re-epithelialization. It examines the principles of cell-based skin regeneration, comparing autologous and allogeneic therapeutic strategies, stem cell sources, and delivery platforms including scaffolds, hydrogels, and bioengineered skin substitutes. Clinical evidence demonstrates that bilayered constructs have superior clinical outcomes compared with monotherapies, in burn care and chronic wound management.The review seeks to highlight current limitations and future directions, including scaffold optimization and appendage regeneration, to advance the development of more functional and durable skin substitutes for wound healing.
Indexed as
Identifiers
42467115What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.