ReviewMolecular biology reports2026
Prolactin as an immuno-neuroendocrine integrator: linking immune homeostasis, hematopoietic dynamics and iron metabolism.
Review in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
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0 citing papers in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prolactin (PRL) is traditionally recognized for its essential role in lactation and reproductive physiology. However, growing evidence establishes PRL as a pleiotropic immuno-neuroendocrine hormone with broad regulatory effects on innate and adaptive immunity, hematopoiesis, and inflammatory homeostasis. It exerts its actions through prolactin receptor that activate intracellular signaling cascades including JAK2/STAT5, MAPK/ERK, and PI3K/Akt pathways. These signaling networks influence lymphocyte survival, cytokine production, macrophage activation, dendritic cell maturation, and hematopoietic progenitor cell expansion. Notably, prolactin demonstrates context-dependent duality, exhibiting both pro-inflammatory and immunoregulatory functions. Dysregulated prolactin signaling has been implicated in autoimmune disorders such as systemic lupus erythematosus, rheumatoid arthritis, and multiple sclerosis. Additionally, prolactin interacts with the hypothalamic-pituitary-adrenal axis, dopaminergic pathways, and sex steroids, integrating neuroendocrine signals with immune responses. This review synthesizes mechanistic insights into prolactin biology, examines its hematopoietic and immunologic roles, critically evaluates current controversies, and discusses emerging therapeutic strategies targeting PRL signaling. Understanding context-specific actions of prolactin may enable precision-based immunomodulatory interventions.
Indexed as
Identifiers
42467144What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.