ArticleScience advances2026
Disease landscape-guided design of neutrophil-specific reporters for early and accurate pneumonia detection in vivo and in urine.
Zhen Li, Tong Li, Keyang Li, Maochao Zheng, Lili Chen, Jialong Sun, Yanhui Li, Shasha He, Huayu Tian
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In one paragraphArticle in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
9 authors.
Zhen LiCollege of Chemistry and Chemical Engineering, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), State Key Laboratory of Vaccines for Infectious Diseases, Xiamen University, Xiamen 361005, China.ORCID 0009-0002-7018-3095 Tong LiCollege of Chemistry and Chemical Engineering, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), State Key Laboratory of Vaccines for Infectious Diseases, Xiamen University, Xiamen 361005, China.
Keyang LiCollege of Chemistry and Chemical Engineering, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), State Key Laboratory of Vaccines for Infectious Diseases, Xiamen University, Xiamen 361005, China.
Maochao ZhengCollege of Chemistry and Chemical Engineering, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), State Key Laboratory of Vaccines for Infectious Diseases, Xiamen University, Xiamen 361005, China.
Lili ChenDepartment of Radiology, Xiang'an Hospital of Xiamen University, Xiamen 361005, China.
Jialong SunCollege of Chemistry and Chemical Engineering, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), State Key Laboratory of Vaccines for Infectious Diseases, Xiamen University, Xiamen 361005, China.
Yanhui LiSchool of Materials Science and Engineering, Xiamen University of Technology, Xiamen 361024, China.
Shasha HeCollege of Chemistry and Chemical Engineering, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), State Key Laboratory of Vaccines for Infectious Diseases, Xiamen University, Xiamen 361005, China.ORCID 0000-0003-0079-8625 Huayu TianCollege of Chemistry and Chemical Engineering, Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province (IKKEM), State Key Laboratory of Vaccines for Infectious Diseases, Xiamen University, Xiamen 361005, China.ORCID 0000-0002-2482-3744 Funding
No grant is acknowledged in the PubMed record.
6 · The paper itselfAbstract
Accurate and early detection of pneumonia is crucial for effective treatment; however, current diagnostic methods often lack the necessary specificity and sensitivity. Herein, we begin with a comprehensive bioinformatics analysis, identifying neutrophil elastase (NE) as a critical biomarker associated with pneumonia progression. We subsequently develop an NE-responsive probe (NERP), composed of a hemicyanine fluorophore linked to an NE-sensitive peptide, specifically designed for activation in inflamed tissues. To facilitate urinalysis, NERP is further refined into a hydrophilic active targeting responsive probe (ATRP
Indexed as
Leukocyte ElastaseNeutrophilsPneumoniaAnimalsBiomarkersHumansMiceBiomarkersLeukocyte Elastase
Identifiers
PMID42467766
PMCPMC13378578
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