Evidence map›Paper›PMID 42467784›Full record

ArticleScience advances2026

Fibroblast-specific ablation of MHC-I antigen presentation via the IGF2 axis cripples CD8

Daqiang Song, Xiaofang Li, Qian Xiao, Hongtao Tie, Qianxue Wu, Yu Shi, Guomin Ye, Jiazheng Sun, Jiazhou Liu, Mingjing Chen and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Daqiang SongDepartment of Breast and Thyroid Surgery, Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID 0009-0007-4091-4455
Xiaofang LiDepartment of Breast and Thyroid Surgery, Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Qian XiaoDepartment of Breast and Thyroid Surgery, Women and Children's Hospital of Chongqing Medical University, Chongqing, China.
Hongtao TieDepartment of Thoracic Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID 0000-0003-1058-6407
Qianxue WuDepartment of Breast and Thyroid Surgery, Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID 0000-0002-9025-624X
Yu ShiDepartment of Breast and Thyroid Surgery, Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Guomin YeDepartment of Breast and Thyroid Surgery, Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Jiazheng SunDepartment of Breast and Thyroid Surgery, Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID 0000-0003-2512-7887
Jiazhou LiuDepartment of Breast and Thyroid Surgery, Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Mingjing ChenDepartment of Breast and Thyroid Surgery, Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhu QiuDepartment of Breast and Thyroid Surgery, Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Weiyan PengDepartment of Breast and Thyroid Surgery, Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Long MengDepartment of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID 0000-0003-0362-8955
Guosheng RenDepartment of Breast and Thyroid Surgery, Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID 0000-0002-6416-8967
Jing HuangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID 0000-0002-5950-4612
Hongzhong LiDepartment of Breast and Thyroid Surgery, Chongqing Key Laboratory of Molecular Oncology and Epigenetics, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID 0000-0003-1136-5235

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

How cancer-associated fibroblasts (CAFs) dictate CD8

Indexed as

Antigen PresentationCancer-Associated FibroblastsCD8-Positive T-LymphocytesHistocompatibility Antigens Class IImmunologic SurveillanceInsulin-Like Growth Factor IILung NeoplasmsAnimalsCell Line, TumorHumansMiceSignal TransductionHistocompatibility Antigens Class IIGF2 protein, humanInsulin-Like Growth Factor II

Identifiers

PMID42467784
PMCPMC13378554

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.