Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Anh Quynh Nguyen DoDepartment of Biological Sciences, Towson University, Towson, MD, USA.
Paula Ramos-GonzalezAchucarro Basque Center for Neuroscience, The Basque Biomodels Platforms for Human Research, Leioa, Spain.ORCID 0000-0003-4825-5769
Carlos MatuteDepartment of Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Spain.ORCID 0000-0001-8672-711X
Ugne KuliesiuteInstitute of Biosciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania.ORCID 0000-0002-2097-4035
Sari Elena DöttererInstitute of Biosciences, Life Sciences Center, Vilnius University, Vilnius, Lithuania.ORCID 0009-0001-0185-6877
Gediminas LuksysFaculty of Medicine, Translational Health Research Institute, Vilnius University, Vilnius, Lithuania.ORCID 0009-0005-8914-117X
Saulius RockaFaculty of Medicine, Translational Health Research Institute, Vilnius University, Vilnius, Lithuania.ORCID 0000-0002-9715-641X
Urte NeniskyteCIBERNED, Madrid, Spain.
Daniel C AnthonyDepartment of Pharmacology, University of Oxford, Oxford, UK.ORCID 0000-0003-1380-6655
Marya AyubDepartment of Neuroscience, Scuola Internazionale Superiore di Studi Avanzati (SISSA), Trieste, Italy.ORCID 0000-0002-1609-5281
Cinzia CentellegheDepartment of Comparative Biomedicine and Food Science, University of Padua, Padua, Italy.ORCID 0000-0002-7577-2107
Carmen FalconeDepartment of Biological Sciences, Towson University, Towson, MD, USA.ORCID 0000-0001-9892-1171
Funding
University of Maryland FIRST ProgramU54CA272205 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI JAMES B KAPER, William Richard LaCourse · 2022 to 2026
$18.1M
NCI NIH HHS U54 CA272205
6 · The paper itself
Abstract
Astrocytes play essential roles in neuropathology. Human astrocytes exhibit unique properties, highlighting the importance of studying astrocytic responses in human models. Varicose projection astrocytes, previously considered exclusive to hominoids and a physiological type of astrocytes, were suggested to reflect pathological burden, albeit direct evidence linking them to neurological diseases has been lacking. Here, we demonstrate that varicose projection astrocytes also appear in other mammals and show, from four distinct human-based disease models, that varicose projection astrocytes are induced by neuroinflammation and characterized by distinctive subcellular features, indicating involvement in cellular stress responses, and their density is increased in aging and human neuropathology. Our findings establish varicose projection astrocytes as a reactive phenotype associated with neuropathology.
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.
Varicose projection astrocytes: Conserved reactive cells in brain pathology. · full record | Socratic