Evidence map›Paper›PMID 42467792›Full record

ArticleScience advances2026

Hyperwrinkling of the nuclear lamina is associated with attenuated mechanosensitivity in giant nucleated cancer cells.

Samere Abolghasemzade, Ryan Blanchard, Chance French, Christina R Dollahon, Harrison Pham, Aidan Atkins, Richard B Dickinson, Tanmay P Lele

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Samere AbolghasemzadeDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, USA.ORCID 0009-0007-4109-2465
Ryan BlanchardDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, USA.ORCID 0000-0002-6946-6664
Chance FrenchDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, USA.ORCID 0009-0007-6900-9037
Christina R DollahonDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, USA.ORCID 0000-0003-2628-5342
Harrison PhamDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, USA.ORCID 0009-0000-9754-0350
Aidan AtkinsDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, USA.ORCID 0000-0002-8455-3942
Richard B DickinsonDepartment of Chemical Engineering, University of Florida, Gainesville, FL, USA.
Tanmay P LeleDepartment of Biomedical Engineering, Texas A&M University, College Station, TX, USA.ORCID 0000-0001-8574-1251

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polyploid giant cancer cells (PGCCs) are chemoresistant tumor cells associated with poor patient outcomes. PGCCs in tissue are identified by their extremely large sizes and the presence of massive or several nuclei. Although nuclear dysmorphia is also a common characteristic of tumor cells, little is known about the shape of nuclei in PGCCs. We show that the nuclear lamina in giant nucleated PGCCs is highly wrinkled across diverse cancer patient tissues. We investigated the cause of this hyperwrinkling in ovarian PGCCs in vitro. Laminar hyperwrinkling in PGCCs was independent of cell shape or cytoskeletal forces. Instead, measurements combined with computational modeling show that laminar hyperwrinkling is an intrinsic property of PGCCs, arising from a disproportionate amount of laminar excess area. PGCCs also displayed attenuated mechanosensitivity of cell spreading and YAP nuclear localization compared with control cells. Thus, laminar hyperwrinkling may disrupt PGCC mechanobiological pathways, slowing their proliferation.

Indexed as

Giant CellsMechanotransduction, CellularNeoplasmsNuclear LaminaOvarian NeoplasmsCell Line, TumorCell NucleusCell ProliferationCytoskeletonFemaleHumansPolyploidy

Identifiers

PMID42467792
PMCPMC13378562

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.