Evidence map›Paper›PMID 42467924›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

SOX5 Orchestrates Malignant Evolution via Promoter-Centric Chromatin Remodeling in MYC-Driven B-Cell Lymphoma.

Yiyou Mao, Zhenyuan Jia, Xiao-Qin Mu, Ruilin Wang, Jianli Ma, Qingyuan Zhang, Yuwei Deng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yiyou MaoDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Zhenyuan JiaDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.
Xiao-Qin MuDepartment of Genomics, Genomics Research Center (Key Laboratory of Gut Microbiota and Pharmacogenomics of Heilongjiang Province), College of Pharmacy, Harbin Medical University, Harbin, China.
Ruilin WangDepartment of Hematology and Endocrinology, 962ed Hospital of Joint Logistic Support Force of the Chinese People's Liberation Army, China.
Jianli MaDepartment of Radiation Oncology, Harbin Medical University Cancer Hospital, Harbin, China.ORCID https://orcid.org/0009-0008-0362-7075
Qingyuan ZhangDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.ORCID https://orcid.org/0000-0001-8116-5293
Yuwei DengDepartment of Medical Oncology, Harbin Medical University Cancer Hospital, Harbin, China.ORCID https://orcid.org/0000-0002-1480-6262

Funding

Haiyan Foundation Outstanding Young Scholar Program JJYQ2024-01Heilongjiang Provincial Natural Science Outstanding Youth Project YQ2023H021Key Research and Development Program Project of Heilongjiang Province 2023ZX06C08the New Era Longjiang Excellent Doctoral Dissertation Project LJYXL2022-65the Youth Project of the National Natural Science Foundation of China 82303299
6 · The paper itself

Abstract

Early events that bias germinal-center B cells toward malignant evolution remain incompletely defined. Here, we uncover Sex-determining Region Y Box 5 (SOX5) as an early-stage epigenetic modifier in myelocytomatosis oncogene (MYC)-driven B-cell lymphoma. Single-cell transcriptomics of lymph nodes from CRISPR/Cas9-engineered Myc

Indexed as

AAV6‐shRNA therapyMYC‐driven B‐cell lymphomaPCNPpromoter‐proximal accessibilitySOX5

Identifiers

PMID42467924
PMCPMC13379260

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.