Evidence map›Paper›PMID 42468146›Full record

ArticlePoultry science2026

Identification of long noncoding RNA LOC416755 and its polymorphisms associated with carcass traits in chicken.

Yaohua Li, Jiahao Li, Siyu Guo, Xinyi Zheng, Wanxi He, Zihan Sun, Bolin Cai

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Article in Poultry science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Yaohua LiState Key Laboratory of Swine and Poultry Breeding Industry, Lingnan Guangdong Laboratory of Agriculture, College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China; Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, Guangdong, China.
Jiahao LiState Key Laboratory of Swine and Poultry Breeding Industry, Lingnan Guangdong Laboratory of Agriculture, College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China; Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, Guangdong, China.
Siyu GuoState Key Laboratory of Swine and Poultry Breeding Industry, Lingnan Guangdong Laboratory of Agriculture, College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China; Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, Guangdong, China.
Xinyi ZhengState Key Laboratory of Swine and Poultry Breeding Industry, Lingnan Guangdong Laboratory of Agriculture, College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China; Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, Guangdong, China.
Wanxi HeState Key Laboratory of Swine and Poultry Breeding Industry, Lingnan Guangdong Laboratory of Agriculture, College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China; Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, Guangdong, China.
Zihan SunState Key Laboratory of Swine and Poultry Breeding Industry, Lingnan Guangdong Laboratory of Agriculture, College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China; Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, Guangdong, China.
Bolin CaiState Key Laboratory of Swine and Poultry Breeding Industry, Lingnan Guangdong Laboratory of Agriculture, College of Animal Science, South China Agricultural University, Guangzhou 510642, Guangdong, China; Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, and Key Laboratory of Chicken Genetics, Breeding and Reproduction, Ministry of Agriculture, Guangzhou 510642, Guangdong, China; Cardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, 169857, Singapore. Electronic address: bolincai@scau.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Long non-coding RNAs (lncRNAs) are known to regulate skeletal muscle development in mammals, but their roles and potential as genetic markers in chickens remain largely unknown. Carcass traits such as breast muscle weight and body weight are economically important in poultry production. Based on our previous RNA-seq data (accession number PRJNA751251), LOC416755 is differentially expressed between the Soleus (SOL) and Pectoralis major (PEM) in Xinghua (XH) chickens. In this study, we further revealed that LOC416755 was highly expressed in the PEM, localized in the nucleus of chicken primary myoblasts, and progressively upregulated during myoblast differentiation. Nine SNPs were identified within LOC416755. Association analysis revealed that SNP1, SNP2, SNP4, SNP5, and SNP7 were significantly associated with shank length, full-bore weight, breast muscle weight, body weight, and abdominal fat weight (P < 0.05). Linkage disequilibrium analysis defined two haplotype blocks, and haplotype variation within block 2 showed a significant association with shank length. The heterozygous genotype consistently exhibited superior phenotypic values for most associated traits. Collectively, these results suggest a potential role for LOC416755 in skeletal muscle development and highlight its potential as a molecular marker for marker-assisted selection to accelerate breed improvement in chickens.

Indexed as

Carcass traitChickenLOC416755Single nucleotide polymorphism

Identifiers

PMID42468146
PMCPMC13400867

What Socratic holds

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.