ReviewBiological psychiatry2026
Impaired Activity-Regulated Proteostasis: A Shared Mechanism in Neurodevelopmental Disorders.
Review in Biological psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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1 author.
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Abstract
Proteostasis is the process by which cells control how much of each protein is made, how long it persists, and when it is removed. In neurons, proteostasis is not merely a housekeeping function; it is actively regulated by neuronal activity. When neurons fire, protein synthesis and degradation are simultaneously and transiently regulated to support synaptic plasticity. In neurodevelopmental disorders (NDDs), neurons lose this capacity to dynamically regulate their proteome in response to stimulation, disrupting synaptic plasticity and leading to cognitive impairments. This review establishes that despite diverse genetic origins, failure of activity-regulated proteostasis is a shared vulnerability across NDDs. This framework also explains why increasing or blocking protein synthesis or degradation alone under basal conditions is insufficient to restore normal function. Restoring the coupling between neuronal activity and proteostatic response rescues both molecular and cognitive impairments in NDDs, which offers a new perspective for investigating disease biology and developing novel therapeutic strategies.
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