Evidence map›Paper›PMID 42468962›Full record

Observational studyBMJ open2026

Neurocognitive and psychological symptoms in post COVID-19 patients (PASC24): prospective cohort study protocol.

Adrian Meehan, Zbigniew Dzialanski, Hans Hjelmqvist, Per Julin, Per Thunberg, Yvonne Freund-Levi

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in BMJ open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06298006 (Uppföljning av Psykiatriska, Kognitiva Och Neurologiska Symtom Hos Post COVID-19 Patienter.), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06298006 active not recruitingnot on this map

Uppföljning av Psykiatriska, Kognitiva Och Neurologiska Symtom Hos Post COVID-19 Patienter.

TypeobservationalSponsorRegion Örebro CountyRan2022 to 2027Enrolled57ConditionsCOVID-19ArmsFollow-up
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Adrian Meehan *School of Medical Sciences, Örebro University, Örebro, Sweden.
Zbigniew Dzialanski *School of Medical Sciences, Örebro University, Örebro, Sweden.
Hans HjelmqvistSchool of Medical Sciences, Örebro University, Örebro, Sweden.
Per JulinDepartment NVS, Karolinska Institutet, Stockholm, Sweden.
Per ThunbergSchool of Medical Sciences, Örebro University, Örebro, Sweden.
Yvonne Freund-LeviSchool of Medical Sciences, Örebro University, Örebro, Sweden Yvonne.Freund@oru.se.ORCID http://orcid.org/0000-0001-6863-6679

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionKnowledge about the late effects of COVID-19, or so-called post-acute sequelae of COVID (PASC), and its pathogenesis is still very limited. The purpose of this observational study is to chart late neurocognitive effects of the COVID-19 infection. The aim is to increase knowledge of the underlying biological processes and describe how biomarkers correlate with degree of symptoms, mapping their role as diagnostic markers over time (24 months). METHODS AND ANALYSIS: This prospective observational cohort study is longitudinal and monitors patients with neurocognitive and psychological symptoms after COVID-19 infection in order to analyse the impact on the brain. For these purposes, we introduce a digital neuropsychological platform (Mindmore). We also aim to analyse potential diagnostic and prognostic markers from blood and cerebrospinal fluid and use MRI of the brain. We will measure the patients' return to work and studies as well as any impact on their ADL functions and quality of life. The ongoing study aims to follow-up to 100 study participants with PASC for 24 months at three visits: baseline, 12 months and 24 months. The findings of the study can be used as guidance for future policy management in healthcare and may lead to a possible curative or symptom-relieving treatment. ETHICS AND DISSEMINATION: This study was approved by the Swedish Ethical Review Authority (diary number: 2020-0604 (main application), 2021-03205, 2023-00023-02, 2024-00426-02 (amendments)). Participants will be required to provide informed consent. The results of this study will be reported in peer-reviewed journals and presented at scientific conferences. TRIAL REGISTRATION NUMBER: NCT06298006.

Indexed as

COVID-19BiomarkersBrainFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingNeuropsychological TestsPost-Acute COVID-19 SyndromeProspective StudiesQuality of LifeResearch DesignSARS-CoV-2BiomarkersBrainCognitive dysfunctionDigital TechnologyMagnetic Resonance ImagingPost-Acute COVID-19 Syndrome

Identifiers

PMID42468962
PMCPMC13384184

What Socratic holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.