Evidence map›Paper›PMID 42469427›Full record

ReviewNature reviews. Chemistry2026

Sequence-defined polymers for predictable gene delivery.

Cameron W Evans, Cooper M Kyrwood, Lennart J Schaefer, James L Wood, Kai Chen, Craig A Bell, Kristofer J Thurecht, Xiaojuan Qi, Haibo Jiang, Cameron Alexander and 3 more

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Cameron W EvansSchool of Pharmacy and Pharmacology, University of Tasmania, Sandy Bay, Tasmania, Australia. cameron.evans@utas.edu.au.ORCID 0000-0003-2312-9803
Cooper M KyrwoodSchool of Molecular Sciences, The University of Western Australia, Crawley, Western Australia, Australia.ORCID 0009-0003-9389-7397
Lennart J SchaeferSchool of Molecular Sciences, The University of Western Australia, Crawley, Western Australia, Australia.ORCID 0000-0001-7032-8974
James L WoodAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0001-8755-779X
Kai ChenSchool of Biomedical Sciences, The University of Western Australia, Crawley, Western Australia, Australia.
Craig A BellAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia.
Kristofer J ThurechtAustralian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, Queensland, Australia.ORCID 0000-0002-4100-3131
Xiaojuan QiDepartment of Electrical and Electronic Engineering, University of Hong Kong, Pok Fu Lam, Hong Kong.
Haibo JiangSchool of Molecular Sciences, The University of Western Australia, Crawley, Western Australia, Australia.
Cameron AlexanderSchool of Pharmacy, University of Nottingham, Nottingham, UK.ORCID 0000-0001-8337-1875
Sébastian PerrierDepartment of Chemistry, University of Warwick, Coventry, UK.ORCID 0000-0001-5055-9046
Vincent M RotelloDepartment of Chemistry, University of Massachusetts, Amherst, MA, USA.
K Swaminathan IyerSchool of Molecular Sciences, The University of Western Australia, Crawley, Western Australia, Australia. swaminatha.iyer@uwa.edu.au.ORCID 0000-0001-9329-4930

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polymer-mediated gene delivery is evolving from stochastic design methodologies to precise molecular engineering. Traditional polymers, although effective in nucleic acid complexation, face challenges in terms of structural heterogeneity, unpredictable pharmacokinetics and inefficient endosomal escape. These challenges have driven interest in sequence-defined polymeric systems, which enable atomic-level control over monomer composition, charge distribution and functionality. Sequence-defined polymers provide opportunities to establish robust structure-function relationships, overcome biological barriers and achieve targeted delivery to specific tissues. This Review examines the architectural evolution of polymeric gene carriers and highlights how increasing structural precision correlates with enhanced functional performance. Synthetic methodologies enabling sequence control are analysed, from solid-phase approaches to flow chemistry and supramolecular templating. By integrating polymer science with biological outcomes, we present a strategic framework for addressing persistent challenges in non-viral gene delivery.

Indexed as

Gene Transfer TechniquesPolymersAnimalsHumansPolymers

Identifiers

PMID42469427

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.