Evidence map›Paper›PMID 42469558›Full record

ReviewDiscover oncology2026

Applications of circulating tumor cells in esophageal cancer detection and treatment.

Fangyuan Long, Shungeng Zhang, Zongfu Dong, Xupeng Huang, Dingfei Li, Ronghang Hu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fangyuan Long *Affiliated Hospital of Jining Medical University, No. 89, Guhuai Road, Jining, 272000, Shandong Province, China.ORCID http://orcid.org/0009-0009-0600-3134
Shungeng Zhang *Shandong First Medical University, Jinan, 250117, Shandong Province, China.
Zongfu DongAffiliated Hospital of Jining Medical University, No. 89, Guhuai Road, Jining, 272000, Shandong Province, China.
Xupeng HuangJining Medical University, Jining, 272000, Shandong Province, China.
Dingfei LiAffiliated Hospital of Jining Medical University, No. 89, Guhuai Road, Jining, 272000, Shandong Province, China.
Ronghang HuAffiliated Hospital of Jining Medical University, No. 89, Guhuai Road, Jining, 272000, Shandong Province, China. ronghanghu@163.com.ORCID http://orcid.org/0009-0001-6515-2529

Funding

Clinical Research Project of Jining Medical College Affiliated Hospital LCYJ-18
6 · The paper itself

Abstract

Esophageal cancer (EC) is highly invasive, recurrent, and metastatic, with high incidence and mortality rates, particularly in China, where it remains endemic. Although metastasis has traditionally been considered a late event in tumor progression, increasing experimental and clinical evidence suggests that dissemination of tumor cells may occur at earlier disease stages than previously recognized [1]. Detection of circulating tumor cells (CTCs) in the bloodstream may indicate tumor dissemination, making CTCs a key factor in the metastatic cascade. In recent years, despite progress in CTC research, there is still a lack of systematic and significant evidence to confirm the diagnostic, monitoring, and prognostic value of CTCs in EC. This review aims to summarize current evidence on the relationship between CTCs and EC and to provide insights that may support improved management and treatment strategies for EC.

Indexed as

Circulating Tumor CellsEsophageal cancerImmunotherapyLiquid biopsyNeoadjuvant therapy

Identifiers

PMID42469558
PMCPMC13388879

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.