ArticleScience China. Life sciences2026
5-FU chemotherapy induces functional CD7
Article in Science China. Life sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
5-Fluorouracil (5-FU) is the cornerstone of chemotherapy for patients with advanced colorectal cancer. 5-FU acts primarily by inhibiting thymidylate synthase to prevent DNA and RNA synthesis, causing apoptosis in rapidly dividing cancer cells. Emerging literature indicates that 5-FU also suppresses tumor development by activating tumor-reactive T cells. However, the mechanism underlying 5-FU function in T cell activation in human colorectal cancer remains incompletely understood. In a comparative screening of human colorectal tumor tissues, we found that the levels of CD7
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.