Evidence map›Paper›PMID 42469951›Full record

ArticleGenes to cells : devoted to molecular & cellular mechanisms2026

RNA-Seq Profiling Reveals Transcriptional Changes in Phosphorylation-Site Mutants of Brg1.

Ayuko Kimura, Jun Nakabayashi, Osamu Ohara, Yayoi Kimura

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Genes to cells : devoted to molecular & cellular mechanisms, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. RNA-Seq Profiling Reveals Transcriptional Changes in Phosphorylation-Site Mutants of Brg1.Genes to cells : devoted to molecular & cellular mechanisms · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Ayuko KimuraGraduate School of Health Sciences, Gunma Paz University, Takasaki City, Gunma, Japan.ORCID https://orcid.org/0000-0003-1315-1118
Jun NakabayashiAdvanced Medical Research Center, Yokohama City University, Yokohama, Kanagawa, Japan.
Osamu OharaDepartment of Applied Genomics, Kazusa DNA Research Institute, Kisarazu, Chiba, Japan.
Yayoi KimuraAdvanced Medical Research Center, Yokohama City University, Yokohama, Kanagawa, Japan.ORCID https://orcid.org/0000-0002-4612-4602

Funding

KAKENHI 15K19028KAKENHI 24K10098
6 · The paper itself

Abstract

Brg1 is a core ATPase subunit of the SWItch/Sucrose Non-Fermentable (SWI/SNF) chromatin-remodeling complex that regulates DNA accessibility for RNA polymerase II (Pol II), transcription factors, and DNA repair enzymes. Phosphoproteomic profiling of highly malignant ovarian clear cell carcinoma (OCCC) cell lines revealed reduced levels of several SWI/SNF components and decreased Brg1 phosphorylation within its histone-binding region. Prior work showed that phosphorylation-mimic and phosphorylation-deficient mutants alter chromatin-silencing factors, producing chromatin condensation and decondensation, respectively. Here, we performed RNA-seq in Brg1-deficient JHOC-5 cells and in isogenic cells expressing Brg1-WT, phosphorylation-mimic brg1-S

Indexed as

DNA HelicasesNuclear ProteinsTranscription FactorsApoptosisCell Line, TumorFemaleGene Expression Regulation, NeoplasticHumansMutationOvarian NeoplasmsPhosphorylationRNA-SeqTranscription, GeneticDNA HelicasesNuclear ProteinsSMARCA4 protein, humanTranscription FactorsapoptosisBRG1ovarian cancerphosphorylationSWI/SNF complex

Identifiers

PMID42469951
PMCPMC13379595

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.