Observational studyMedicine2026
GPER, 8-isoprostaglandin, and tau protein as potential biomarkers in supraventricular tachycardia: An observational study.
Observational study in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Supraventricular tachycardia (SVT) is a common arrhythmic disorder characterized by abnormal electrical impulses arising from supraventricular tissues, most commonly the atria or atrioventricular node. This study aimed to investigate the association between G protein-coupled estrogen receptor (GPER) levels and biomarkers of oxidative stress and neurodegeneration in the pathophysiology of SVT. This study included 51 patients diagnosed with SVT and 30 healthy controls. Plasma levels of the oxidative stress marker 8-iso-prostaglandin F2α (8-iso-PGF2α), the neurodegeneration-associated protein Tau, and GPER were measured using ELISA kits. Correlations between GPER and the studied biomarkers were analyzed, and the diagnostic performance of each biomarker was evaluated using ROC analysis. Pro-BNP levels were higher in patients with SVT compared to the control group (P = .05). GPER, Tau, and 8-iso-PGF2α levels were significantly higher in the SVT group compared to the control group (P < .001 for all 3 biomarkers). ROC analysis demonstrated that 8-iso-PGF2α had the highest diagnostic accuracy, while Tau (AUC = 0.986) and GPER (AUC = 0.981) also showed strong discriminative performance. GPER, a well-established marker of estrogen-mediated cellular signaling, emerges as a significant biomarker in patients with SVT. These findings suggest that GPER-mediated signaling pathways may be associated with systemic oxidative damage and neuronal effects in the pathophysiology of SVT.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.