ArticleCancer medicine2026
Revealing the Interactions of Regulatory Factors in the Immune Microenvironment of Breast Cancer Based on Two-Way Orthogonal Partial Least Square Model and Cell Communication.
Article in Cancer medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The treatment with immune checkpoint inhibitors is not universally effective, and the efficacy is challenging to predict using a single biomarker. Breast cancer (BC) cells develop within a complex microenvironment, which includes tumor cells, immune cells, and extracellular matrix, and they may interact through paracrine signaling. Elucidating the mechanisms of immune microenvironment regulation and intercellular interactions in BC is fundamental for screening efficacy markers and developing new immunotherapeutic targets. Based on the immune phenotype cellular infiltration characteristics and transcriptomic changes, we constructed a two-way orthogonal partial least square (O2PLS) model to identify immune cell infiltration (ICI) genes, quantitatively characterizing the immune microenvironment within BC to predict patient prognosis, select sensitive populations for immunotherapy, and provide a theoretical basis for the combination of immunotherapy with radiotherapy and chemotherapy. We described the T cell differentiation trajectories and intercellular communication landscapes and revealed the synergistic effects of receptors and ligands (CXCL9-CXCR3, CCL5-ACKR1, and GZMA-F2R) on the immune microenvironment and prognosis. These findings may contribute to elucidating the factors that shape the immune microenvironment and identifying new therapeutic targets.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.