Regional differences in foveal avascular zone morphology in cynomolgus macaques using a normative OCTA database.

Claudia Bruè, Peter M Maloca, Cathy Cukras, Philippe Valmaggia, Nora Denk

Abstract read

In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Claudia BruèOphthalmic clinic, Macerata Hospital, Macerata, Italy.

Peter M Maloca *Department of Ophthalmology, University Hospital Basel, Basel, 4031, Switzerland. peter.maloca@unibas.ch.ORCID 0000-0002-4794-5859

Cathy CukrasRoche Pharma Research and Early Development Ophthalmology, Roche, US.

Philippe ValmaggiaDepartment of Ophthalmology, University Hospital Basel, Basel, 4031, Switzerland.

Nora Denk *Department of Ophthalmology, University Hospital Basel, Basel, 4031, Switzerland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cynomolgus macaques are widely used in preclinical ophthalmic research because of their close anatomical and physiological similarity to the human eye. However, the small cohort sizes typical of laboratory studies and the limited implementation of automated image analysis have restricted the availability of robust normative datasets. In particular, comprehensive reference values for foveal avascular zone (FAZ) measurements in laboratory cynomolgus monkeys remain scarce. To address this, an automated OCT/OCTA image-processing workflow was used to quantify FAZ morphology in healthy cynomolgus monkeys, including a deep learning-based OCT segmentation step followed by analysis of the corresponding OCTA data. The study also evaluated morphological variations as well as the influence of sex and geographical origin. The overall FAZ area measured 0.451 mm (range 0.132-0.820 mm

Indexed as

Fovea CentralisTomography, Optical CoherenceAnimalsDatabases, FactualFemaleImage Processing, Computer-AssistedMacaca fascicularisMaleReference ValuesCynomolgus macaquesFoveal avascular zoneOriginRetinaVessel density

Identifiers

PMID42471406

DOI10.1038/s41598-026-60198-2

PMCPMC13392401

What Socratic holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.