Evidence map›Paper›PMID 42471933›Full record

ArticleAnnals of intensive care2026

Extracorporeal circuit temperature gradient and hemodynamic instability during continuous renal replacement therapy: an observational study.

Lorna Fraire, Téo Keraron, Matthieu Chivot, Hodane Yonis, Guillaume Chazot, Mehdi Mezidi, Louis Chauvelot, Guillaume Deniel, Jean-Christophe Richard, Laurent Bitker

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of intensive care, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03139123 (Prevalence of Hypotension Associated With Preload Dependence During Continuous Renal Replacement Therapy), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03139123 completednot on this map

Prevalence of Hypotension Associated With Preload Dependence During Continuous Renal Replacement Therapy

TypeobservationalSponsorHospices Civils de LyonRan2017 to 2020Enrolled42ConditionsKidney Injury, Renal Failure, AcuteArmsHemodynamic monitoring during passive leg raising
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Lorna FraireService de Médecine Intensive - Réanimation, Hôpital de la Croix Rousse, Hospices Civils de Lyon, France.
Téo KeraronService de Médecine Intensive - Réanimation, Hôpital de la Croix Rousse, Hospices Civils de Lyon, France.
Matthieu ChivotService de Médecine Intensive - Réanimation, Hôpital de la Croix Rousse, Hospices Civils de Lyon, France.
Hodane YonisService de Médecine Intensive - Réanimation, Hôpital de la Croix Rousse, Hospices Civils de Lyon, France.
Guillaume ChazotService de Médecine Intensive - Réanimation, Hôpital de la Croix Rousse, Hospices Civils de Lyon, France.
Mehdi MezidiService de Médecine Intensive - Réanimation, Hôpital de la Croix Rousse, Hospices Civils de Lyon, France.
Louis ChauvelotService de Médecine Intensive - Réanimation, Hôpital de la Croix Rousse, Hospices Civils de Lyon, France.
Guillaume DenielService de Médecine Intensive - Réanimation, Hôpital de la Croix Rousse, Hospices Civils de Lyon, France.
Jean-Christophe RichardService de Médecine Intensive - Réanimation, Hôpital de la Croix Rousse, Hospices Civils de Lyon, France.
Laurent BitkerService de Médecine Intensive - Réanimation, Hôpital de la Croix Rousse, Hospices Civils de Lyon, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Lowering extracorporeal circuit temperature (T° Methods: This ancillary analysis of a prospective, single-center center study (NCT03139123) included patients with stage 3 acute kidney injury, receiving CRRT for <24 h and with continuous cardiac index monitoring. T° Results: 42 patients were enrolled in this ancillary analysis (age 68 [58-76], SOFA 12 [8-15], 79% with sepsis), and were followed over 119 [57-143] hours (N = 1012 observations). Decreasing ΔT° (extracorporeal cooling) was significantly associated with higher heart rate, CO and MAP, lower norepinephrine dose, and was associated with a reduction in HIRRT risk in univariate analysis ( Conclusions: During CRRT, setting the circuit temperature below body temperature was associated with a reduced HIRRT risk, an effect potentially mediated through improvements in MAP and CO.

Indexed as

Cardiac outputContinuous renal replacement therapyHemodynamicsMediationTemperature management

Identifiers

PMID42471933
PMCPMC13380051

What Socratic holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.