Evidence map›Paper›PMID 42472120›Full record

ArticleiScience2026

Setdb1 safeguards proper differentiation of adult intestinal stem cells by controlling chromatin accessibility and transcriptome variability.

Ioanna Peraki, Liwei Zhang, Dimitris Botskaris, Marianna Stagaki, Ioannis K Deligiannis, Haroula Kontaki, Elena Deligianni, Ioannis Giannoulakis, Orsalia Hazapis, Matthieu D Lavigne and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ioanna PerakiInstitute of Molecular Biology & Biotechnology, Foundation for Research and Technology, Hellas (IMBB-FORTH), Heraklion, Crete, Greece.
Liwei ZhangInstitute of Biotechnology and Biomedicine (BIOTECMED), Department of Biochemistry and Molecular Biology, University of Valencia, Burjassot, Spain.
Dimitris BotskarisInstitute of Molecular Biology & Biotechnology, Foundation for Research and Technology, Hellas (IMBB-FORTH), Heraklion, Crete, Greece.
Marianna StagakiInstitute of Molecular Biology & Biotechnology, Foundation for Research and Technology, Hellas (IMBB-FORTH), Heraklion, Crete, Greece.
Ioannis K DeligiannisHelmholtz Pioneer Campus (HPC), Helmholtz Zentrum Munchen, Neuherberg, Germany.
Haroula KontakiInstitute of Molecular Biology & Biotechnology, Foundation for Research and Technology, Hellas (IMBB-FORTH), Heraklion, Crete, Greece.
Elena DeligianniInstitute of Molecular Biology & Biotechnology, Foundation for Research and Technology, Hellas (IMBB-FORTH), Heraklion, Crete, Greece.
Ioannis GiannoulakisInstitute of Molecular Biology & Biotechnology, Foundation for Research and Technology, Hellas (IMBB-FORTH), Heraklion, Crete, Greece.
Orsalia HazapisInstitute of Molecular Biology & Biotechnology, Foundation for Research and Technology, Hellas (IMBB-FORTH), Heraklion, Crete, Greece.
Matthieu D LavigneInstitute of Molecular Biology & Biotechnology, Foundation for Research and Technology, Hellas (IMBB-FORTH), Heraklion, Crete, Greece.
Celia P Martinez-JimenezHelmholtz Pioneer Campus (HPC), Helmholtz Zentrum Munchen, Neuherberg, Germany.
Iannis TalianidisInstitute of Molecular Biology & Biotechnology, Foundation for Research and Technology, Hellas (IMBB-FORTH), Heraklion, Crete, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The histone methylase Setdb1 plays a pivotal role in embryonic stem cell maintenance and developmental lineage specification. However, its function in adult stem cells remains elusive. Here we show that the conditional inactivation of

Indexed as

differentiationgene regulatory networksheterochromatinintestinal stem cellsSetdb1transcriptome variabilityvirtual knock-out

Identifiers

PMID42472120
PMCPMC13380120

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.